TGFB1I1
-
Official Full Name
transforming growth factor beta 1 induced transcript 1 -
Overview
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] -
Synonyms
TGFB1I1;transforming growth factor beta 1 induced transcript 1;HIC5;ARA55;HIC-5;TSC-5;transforming growth factor beta-1-induced transcript 1 protein;androgen receptor coactivator ARA55;hydrogen peroxide-inducible clone 5 protein;androgen receptor coactivator 55 kDa protein;androgen receptor-associated protein of 55 kDa
Recombinant Proteins
- Human
- Rat
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
TGFB1I1 involved in several pathways and played different roles in them. We selected most pathways TGFB1I1 participated on our site, such as Androgen receptor signaling pathway,Coregulation of Androgen receptor activity,Monoamine Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFB1I1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Androgen receptor signaling pathway | KAT7B,RANBP9,PARK7,JUN,CTNNB2,EGFR,EFCAB6,SVILA,RUNX2A,SMARCE1 |
| Coregulation of Androgen receptor activity | KDM4C,CMTM2A,KDM1A,SNURF,CMTM2,NRIP1,PATZ1,CTDSP1,PA2G4,KDM3A |
| Monoamine Transport | UNC13B,FBXO32,SYN1,SCAMP2,DBH,HRH3,TPH2 |
| Serotonin Transporter Activity | SCAMP2,TPH2 |
Protein Function
TGFB1I1 has several biochemical functions, for example, I-SMAD binding,Roundabout binding,androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFB1I1 itself. We selected most functions TGFB1I1 had, and list some proteins which have the same functions with TGFB1I1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| androgen receptor binding | Ar,PRMT2,TCF21,KDM1A,RNF4,PKN1,NRIP1,PRKCB,RB1,EP300 |
| zinc ion binding | SP140L,ABLIM3,RNF144AB,MORC2B,ZFP385C,ZSWIM1,HNF4G,CNBPA,TNFAIP3,P2RX1 |
| protein binding | CCDC109A,STK4,RAB37,FAM109B,PACSIN3,MAGEE1,GATAD2B,DACT2,DDAH2,BAAT |
| I-SMAD binding | CTNNB1,SMURF1,AXIN2,SMAD4,AXIN1,SMAD1,SMAD7,SMAD2,TGFBR1,SMAD6 |
| transcription coactivator activity | RIPK3,DDX17,APEX1,PSMD9,SCAND1,PRMT2,NEUROD1,RFXAP,CRSP7,BRD7 |
| Roundabout binding | SLIT2,SLIT1A,SLIT1,SLIT3,GM4980,UBE4A,SLIT1B |
Interacting Protein
TGFB1I1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFB1I1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFB1I1.
PTK2;ITGA4;VHL;CCNA1;CDKN2B;ilvD;kdpE;kbl;HIPK3;UBQLN4;PLA2G3;q9wmx2-pro_0000037548;SH2D1B;PLEKHH2
Resources
Related Services
Related Products
References
- Derer, S; Till, A; et al. mTNF reverse signalling induced by TNF alpha antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease. GUT 62:376-386(2013).
- Lai, CF; Chen, YM; et al. Cysteine-Rich Protein 61 Plays a Proinflammatory Role in Obstructive Kidney Fibrosis. PLOS ONE 8:-(2013).
