SYT6
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Official Full Name
synaptotagmin VI -
Overview
Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene.Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605. -
Synonyms
SYT6;synaptotagmin VI;synaptotagmin-6;sytVI
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SYT6 involved in several pathways and played different roles in them. We selected most pathways SYT6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SYT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SYT6 has several biochemical functions, for example, calcium ion binding,NOT calcium-dependent phospholipid binding,clathrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYT6 itself. We selected most functions SYT6 had, and list some proteins which have the same functions with SYT6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | FGFR1OP,MAP3K11,FZD9,NPM1,HSPB6,MAP3K12,SMAD1,CHMP4B,TPD52,DMRTA2 |
| protein binding | EIF4EBP3L,CHTOP,SDHA,SPAT-1,ZBP1,TPM4,PRKAB2,VAPB,ARMC2,AIRE |
| clathrin binding | TOM1,RPH3A,SYT9,SYT15,CCDC167,CLINT1,SYTL3,DOC2B,RPH3AL,SYT1 |
| syntaxin binding | VPS52,CPLX4A,SYT13,CPLX4B,SYT5B,STX7,DOC2D,CPLX3,SYT5,NAPA |
| calcium ion binding | SULF2,PNLIPRP2,ADAMTS13,SLIT3,PCDHB15,SLC25A24L,CDH20,RPH3A,C1rb,EGF |
| NOT calcium-dependent phospholipid binding | SYT13,SYT16,SYT11B,MCTP2,SYT14,SYT4,MCTP1 |
Interacting Protein
SYT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYT6.
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References
- Rodriguez, F; Zanetti, MN; et al. Munc18-1 Controls SNARE Protein Complex Assembly during Human Sperm Acrosomal Exocytosis. JOURNAL OF BIOLOGICAL CHEMISTRY 287:43825-43839(2012).
- Bennett, JC; Roggero, CM; et al. Calcineurin-mediated Dephosphorylation of Synaptotagmin VI Is Necessary for Acrosomal Exocytosis. JOURNAL OF BIOLOGICAL CHEMISTRY 285:26269-26278(2010).
