SYNE1

  • Official Full Name

    spectrin repeat containing, nuclear envelope 1

  • Overview

    This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood;lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal;recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive;ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described.

  • Synonyms

    SYNE1;spectrin repeat containing, nuclear envelope 1;C6orf98, chromosome 6 open reading frame 98;nesprin-1;8B;ARCA1;CPG2;dJ45H2.2;enaptin;KIAA0796;MYNE1;Nesprin 1;SCAR8;SYNE 1B;synaptic nuclei expressed gene 1;myocyte nuclear en
Cat.# Product name Source (Host) Species Tag Protein Length Price
SYNE1-377H Recombinant Human SYNE1 Protein, His-tagged E.coli Human His Lys30~Pro283
SYNE1-1319HCL Recombinant Human SYNE1 293 Cell Lysate HEK293 Human Non

    Involved Pathway

    SYNE1 involved in several pathways and played different roles in them. We selected most pathways SYNE1 participated on our site, such as Cell Cycle,Meiosis,Meiotic synapsis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYNE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Meiotic synapsis SYCP2,TINF2,SUN1,FKBP6,DIDO1,STAG2,SYCE1,SYCP1,SYNE2,ACD
    Meiosis SPO11,FKBP6,TERF2,PSMC3IP,POT1,TEX12,SYCE1,MND1,TERF1,STAG1
    Cell cycle YWHAG,CDCA8,CEP78,STAG2,PDS5B,RBBP8,HIST3H2BB,RAD9,TUBG1,THRSP

    Protein Function

    SYNE1 has several biochemical functions, for example, actin binding,actin filament binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYNE1 itself. We selected most functions SYNE1 had, and list some proteins which have the same functions with SYNE1. You can find most of the proteins on our site.

    Function Related Protein
    protein homodimerization activity CIB2,HIF1AN,WWTR1,SYT6,HPGD,STK10,PEX7,MGLL,GSTA4,SLC30A8
    actin binding PLEKHH2,GSN,GMFG,WASL,WASF3B,SNTB1,NF2B,EMD,MACF1,SMYHC2
    poly(A) RNA binding RPS4Y2,NOP2,ZFP326,HMGB1,HUWE1,MRTO4,EIF2AK2,POLR2B,VSIG8,CSDA
    lamin binding PLCB1,TMPO,NARF,LBR,BNIP3L,PPP4C,TOR1AIP1,SUN2,TMEM201,IFI27
    protein binding NFE2L2,GIPC2,FCN3,WDFY3,SNX2,DYNLT3,HNF1B,USP4,U2AF1,PIAS2
    identical protein binding PDCD6,CCDC109A,CLDN1,HTT,ESR1,CLDN23,LYZ2,LCK,SH2B2,CNTN2
    actin filament binding SHROOM4,GAS7,TMOD1,SHROOM1,MYH9A,CORO2B,TRIOBPB,TRPV4,MYO6,ANXA8

    Interacting Protein

    SYNE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYNE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYNE1.

    SUN2;DISC1;Nde1;APC;p29991-pro_0000037946;MYOM1;CDC42;sdhA;tnp_8;TP53RK;q9wmx2-pro_0000037548;ere_dna

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