SUV420H1
-
Official Full Name
suppressor of variegation 4-20 homolog 1 -
Overview
This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript variants have been found for this gene. -
Synonyms
SUV420H1;suppressor of variegation 4-20 homolog 1 (Drosophila);histone-lysine N-methyltransferase SUV420H1;CGI 85;KMT5B;suv4-20h1;C630029K18Rik;su(var)4-20 homolog 1;lysine N-methyltransferase 5B;CGI85;CGI-85;MGC703;MGC21161;MGC118906;MGC118
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Rhesus macaque
- Rat
- Mammalian Cell
- Insect Cell
- E.coli
- HEK293
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
SUV420H1 involved in several pathways and played different roles in them. We selected most pathways SUV420H1 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUV420H1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysine degradation | PLOD1,BBOX1,HADHA,GLT25D1,SUV39H1B,ALDH9A1A.1,SETD8A,SETD1B,GCDHB,DOT1L |
Protein Function
SUV420H1 has several biochemical functions, for example, histone methyltransferase activity (H4-K20 specific),histone-lysine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SUV420H1 itself. We selected most functions SUV420H1 had, and list some proteins which have the same functions with SUV420H1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone methyltransferase activity (H4-K20 specific) | NSD1,SUV420H2,WHSC1 |
| histone-lysine N-methyltransferase activity | KMT2A,SETDB1B,SETDB1A,PRDM6,SETDB1,SETD1BA,SUV39H1B,SMYD3,EHMT1B,SETD1B |
Interacting Protein
SUV420H1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUV420H1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUV420H1.
YWHAQ;YWHAG;pagA;yezC;SMARCD1
Resources
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References
- Li, YL; Choi, PS; et al. MYC through miR-17-92 Suppresses Specific Target Genes to Maintain Survival, Autonomous Proliferation, and a Neoplastic State. CANCER CELL 26:262-272(2014).
- Yokoyama, Y; Matsumoto, A; et al. Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity. BREAST CANCER RESEARCH 16:-(2014).
