SUPT16H
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Official Full Name
suppressor of Ty 16 homolog -
Overview
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. -
Synonyms
SUPT16H;suppressor of Ty 16 homolog (S. cerevisiae);suppressor of Ty (S.cerevisiae) 16 homolog;FACT complex subunit SPT16;CDC68;facilitates chromatin remodeling 140 kDa subunit;FACT;FACTP140;FLJ10857;FLJ14010;SPT16/CDC68;hSPT16;FACT 140 kDa su
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SUPT16H-5647Z | Recombinant Zebrafish SUPT16H | Mammalian Cell | Zebrafish | His |
|
Involved Pathway
SUPT16H involved in several pathways and played different roles in them. We selected most pathways SUPT16H participated on our site, such as Formation of RNA Pol II elongation complex,Gene Expression,RNA Polymerase II Pre-transcription Events, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUPT16H were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA Polymerase II Pre-transcription Events | CCNT2B,GM3258,NELFE,CCNT2A,SSRP1A |
| Gene Expression | PTBP1,PRDM7,TAF1B,ZNF461,ZFP143,Txn1,TUBB3,ZNF12,EFCAB11,ZNF143B |
| Formation of RNA Pol II elongation complex | WHSC2,SSRP1A,CCNT2B,CTDP1,ELL,RDBP,CCNT2A,GM3258,PSTPIP2,COBRA1 |
| RNA Polymerase II Transcription Elongation | CCNT2B,CCNT2A,SSRP1A,GM3258,NELFE |
| RNA Polymerase II Transcription | ZFP473,GM3258,LSM10,CCNT2B,RNPS1,SRSF11,NUDT21,PAPOLA,CSTF2,SSRP1A |
Protein Function
SUPT16H has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SUPT16H itself. We selected most functions SUPT16H had, and list some proteins which have the same functions with SUPT16H. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
SUPT16H has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUPT16H here. Most of them are supplied by our site. Hope this information will be useful for your research of SUPT16H.
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References
- Kruger, AV; Jelier, R; et al. Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis. DEVELOPMENTAL BIOLOGY 398:153-162(2015).
- Prontera, P; Ottaviani, V; et al. Recurrent similar to 100 Kb Microdeletion in the Chromosomal Region 14q11.2, Involving CHD8 Gene, is Associated with Autism and Macrocephaly. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:3137-3141(2014).
