SUGP1
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Official Full Name
SURP and G patch domain containing 1 -
Overview
Retinol-binding protein (RBP) is a small (21kD) transport protein for vitamin A which forms a complex with prealbumin in blood but loses its affinity for prealbumin once the vitamin has been delivered to the target cells. The free RBP molecule is rapidly filtered at the glomerulus and catabolized in the renal tubules after resorption by the proximal tubular cells (like other small molecules e.g. ?-2 microglobulin). In kidney disease with prevailing tubular changes these proteins are not reabsorbed and appear in the urine. As published by Yang et al. (2005) the retinol-binding protein 4 (RBP4) seems to play a key role in the of insulin resistance. The fat cell derived peptide RBP also modulates the glucose homeostasis and impairs the insulin sensitivity as well as insulin resistance. The elevation of serum RBP4 causes systemic insulin resistance, whereas its reduction improves the insulin action. -
Synonyms
RNA-binding protein RBP;SURP and G-patch domain-containing protein 1;splicing factor 4;SUGP1;SURP and G patch domain containing 1;Sf4
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SUGP1 involved in several pathways and played different roles in them. We selected most pathways SUGP1 participated on our site, such as Gene Expression,Processing of Capped Intron-Containing Pre-mRNA,mRNA Splicing, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUGP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Processing of Capped Intron-Containing Pre-mRNA | HNRNPL2,RNPS1,TTC6,HNRNPL,THOC4,HNRNPA0L,SF3A1,CSTF3,PAPOLA,HNRNPA0A |
| mRNA processing | DDX39,RBM5,SFRS3A,PRPF4B,HNRNPABA,ADARB2,EIF4E3,NONO,CELF2,RBMS3 |
| mRNA Splicing - Major Pathway | CD2BP2,HNRNPD,HNRNPA0,PTBP1,HNRNPA2B1,SF3A3,HNRNPL2,HNRNPA0A,HNRNPH2,HNRNPUL1 |
| mRNA Splicing | SF3B2,BCAS2,HNRNPH2,CD2BP2,SF3A3,PRPF8,TTC6,SF3B4,CCAR1,PDCD7 |
| Gene Expression | ZNF706,ZNF287,SAP130,CBX3A,ZNF500,METTL14,EEF1A2,SLBP,APOBEC1,GLS2B |
Protein Function
SUGP1 has several biochemical functions, for example, poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUGP1 itself. We selected most functions SUGP1 had, and list some proteins which have the same functions with SUGP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | SLC25A11,HIST1H4D,SEC23IP,CDC5L,STRBP,MAGOHB,RBMX,HSP90AA1,RPL17,PPAN |
| protein binding | TUBGCP3,RPS27A,SNX20,NDC80,NFKBID,TRPS1,PARD3,LARP2,C3orf15,FGR |
Interacting Protein
SUGP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUGP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUGP1.
U2AF2;DHX15;RBM10;RBM17;SF3A2;TAF9;SNRPB2;ZWINT;RAB5C;SF1;LDHD;Dync1li1;Mis12
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