STXBP5
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Official Full Name
syntaxin binding protein 5 (tomosyn) -
Overview
Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
STXBP5;syntaxin binding protein 5 (tomosyn);LGL3;LLGL3;Nbla04300;syntaxin-binding protein 5;tomosyn;tomosyn-1;putative protein product of Nbla04300;lethal(2) giant larvae protein homolog 3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| STXBP5-5821R | Recombinant Rat STXBP5 Protein | Mammalian Cell | Rat | His |
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| STXBP5-5480R | Recombinant Rat STXBP5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| STXBP5-5480R-B | Recombinant Rat STXBP5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
STXBP5 involved in several pathways and played different roles in them. We selected most pathways STXBP5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with STXBP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
STXBP5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by STXBP5 itself. We selected most functions STXBP5 had, and list some proteins which have the same functions with STXBP5. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
STXBP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STXBP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of STXBP5.
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References
- Ye, SJ; Huang, YJ; et al. Platelet secretion and hemostasis require syntaxin-binding protein STXBP5. JOURNAL OF CLINICAL INVESTIGATION 124:4517-4528(2014).
- Lillicrap, D; et al. Syntaxin-binding protein 5 exocytosis regulation: differential role in endothelial cells and platelets. JOURNAL OF CLINICAL INVESTIGATION 124:4231-4233(2014).
