STRADB
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Official Full Name
STE20-related kinase adaptor beta -
Overview
Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2, is connected to transferase/kinase activity and ATP binding, it has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family. Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1 converting enzyme of Fas-induced apotosis. This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival, suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed. -
Synonyms
Stradb;STE20-related kinase adaptor beta;Papk;ILPIP;ILPIPA;Syradb;Als2cr2;D1Ucla2;PRO1038;AA792893;B830008M19;STE20-related kinase adapter protein beta;STRAD beta;OTTMUSP00000022732;pseudokinase ALS2CR2;ILP-interacting protein homolog;polyploidy associated protein kinase;amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog;Polyploidy-associated protein kinase;CALS-21
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Mammalian Cell
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| STRADB-16171M | Recombinant Mouse STRADB Protein | Mammalian Cell | Mouse | His |
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| STRADB-4536R | Recombinant Rhesus monkey STRADB Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| STRADB-1385HCL | Recombinant Human STRADB 293 Cell Lysate | HEK293 | Human | Non |
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| STRADB-4352R | Recombinant Rhesus Macaque STRADB Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| STRADB-4352R-B | Recombinant Rhesus Macaque STRADB Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| STRADB-8827M | Recombinant Mouse STRADB Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| STRADB-8827M-B | Recombinant Mouse STRADB Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
STRADB involved in several pathways and played different roles in them. We selected most pathways STRADB participated on our site, such as AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STRADB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AMPK signaling pathway | ADIPOR1,GYS1,PFKFB2,CREB3L2,PPP2R5A,PRKAA2,PFKFB3,PIK3R5,PDPK1,PFKM |
Protein Function
STRADB has several biochemical functions, for example, ATP binding,NOT Rac GTPase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STRADB itself. We selected most functions STRADB had, and list some proteins which have the same functions with STRADB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT protein serine/threonine kinase activity | FAM20A,SNX15,STRADA |
| ATP binding | ATP8A1,NLRP7,IGF1RB,CHD7,PRKCZ,MAP4K5,UBE2W,MAPKAPK2B,HSPA9,UBE2G2 |
| protein binding | MID1IP1,NDNL2,PPP3R1,SOSTDC1B,SASS6,RUSC2,RPSA,EGR2,NXF3,MORF4L2 |
| NOT Rac GTPase binding | STRADA |
| NOT protein kinase activity | HSPB8,TRIB2,TRIB1,STRADA,PXK,MLKL |
Interacting Protein
STRADB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STRADB here. Most of them are supplied by our site. Hope this information will be useful for your research of STRADB.
STK11;CAB39;Dlg4;NEB;GRB2
Resources
Related Services
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References
- Veleva-Rotse, BO; Smart, JL; et al. STRAD pseudokinases regulate axogenesis and LKB1 stability. NEURAL DEVELOPMENT 9:-(2014).
- Mikryukov, A; Moss, T; et al. Agonistic and Antagonistic Roles for TNIK and MINK in Non-Canonical and Canonical Wnt Signalling. PLOS ONE 7:-(2012).
