STIL
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Official Full Name
SCL/TAL1 interrupting locus -
Overview
This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
STIL;SCL/TAL1 interrupting locus;SIL, TAL1 (SCL) interrupting locus;SCL-interrupting locus protein;MCPH7;DKFZp686O09161;OTTHUMP00000009566;SCL interrupting locus protein;SIL;STIL_HUMAN;TAL 1 interrupting locus protein;TAL-1-interrupting locus protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| STIL-3004H | Recombinant Human STIL, His-tagged | E.coli | Human | His | 938-1287aa | |
| STIL-9518Z | Recombinant Zebrafish STIL | Mammalian Cell | Zebrafish | His |
|
Involved Pathway
STIL involved in several pathways and played different roles in them. We selected most pathways STIL participated on our site, such as Adipogenesis,Cell Cycle,Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with STIL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Depolymerisation of the Nuclear Lamina | LEMD3,TMPO,CNEP1R1,CTDNEP1,CTDNEP1A,CTDNEP1B,TMEM188,DULLARD |
| Adipogenesis | AHR,AGT,GADD45A,KLF5,MEF2B,NAMPT,KLF7,FOXC2,DVL1,CELF1 |
| Cell Cycle, Mitotic | NUPL2,NUDC,STAG1,MYBL2,CEP76,SPC25,CSNK2A1,CDKN2D,CDCA5,NUMA1 |
| Glycerophospholipid metabolism | AGPAT2,PMT,PPAP2D,DGKAA,PPAP2C,PLD1,AGPAT1,AGXT2L1,GPCPD1,CHKA |
| Glycerophospholipid biosynthesis | AWAT2,PLA2G16,CDIPT,CEPT1,ABHD3,PLD6,CDS1,AGPAT2,PNPLA8,AGPAT6 |
| Glycerolipid metabolism | TAE1,AGPAT3,PPAP2A,AKR1A1,DGKB,LIPCA,PNLIPRP2,ALDH2.2,Akr1b3,AKR1B1L |
| Cell cycle | MPEG1,NDE1,HDAC6,TCTN2,FZR1A,CENPH,CCNH,NSL1,DIDO1,CNEP1R1 |
| Fatty acid, triacylglycerol, and ketone body metabolism | CPT2,G0S2,SLC25A1A,MED9,AGPAT6,MED20,AGPAT1,PPARGC1B,MED19,AGT |
Protein Function
STIL has several biochemical functions, for example, phosphatidate phosphatase activity,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by STIL itself. We selected most functions STIL had, and list some proteins which have the same functions with STIL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | NFE2,MKL1,GABPA,ARL2BP,TCF3,CDK7,GMEB1,FHL2,TADA2A,COPS5 |
| phosphatidate phosphatase activity | LPIN2,LPPR3,PPAPDC1A,PPAP2B,LPIN3,PPAP2C,PPAP2CB,PPAP2A,LPIN1,PPAPDC1B |
Interacting Protein
STIL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STIL here. Most of them are supplied by our site. Hope this information will be useful for your research of STIL.
CENPJ;SASS6
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References
- Amartely, H; Iosub-Amir, A; et al. Identifying Protein-protein Interaction Sites Using Peptide Arrays. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2014).
- del Monte-Martinez, A; Gonzalez-Bacerio, J; et al. Improved purification and enzymatic properties of a mixture of Sticholysin I and II: Isotoxins with hemolytic and phospholipase A(2) activities from the sea anemone Stichodactyla helianthus. PROTEIN EXPRESSION AND PURIFICATION 95:57-66(2014).
