STEAP4
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Official Full Name
STEAP family member 4 -
Overview
The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
STEAP4;STEAP family member 4;TNFAIP9, tumor necrosis factor, alpha induced protein 9;metalloreductase STEAP4;FLJ23153;STAMP2;TIARP;six transmembrane prostate protein 2;sixTransMembrane protein of prostate 2;tumor necrosis factor, alpha-induced p
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Rat
- Mus musculus
- Mammalian Cell
- E.coli
- HEK293
- E.coli expression system
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
STEAP4 involved in several pathways and played different roles in them. We selected most pathways STEAP4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with STEAP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
STEAP4 has several biochemical functions, for example, cupric reductase activity,ferric-chelate reductase (NADPH) activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STEAP4 itself. We selected most functions STEAP4 had, and list some proteins which have the same functions with STEAP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ferric-chelate reductase (NADPH) activity | STEAP3,STEAP2 |
| metal ion binding | ADSSL,CCDC76,CNOT4B,ASAP2A,ZNF823,GDPD3,ZKSCAN1,ZNF643,MICAL2B,C22orf28 |
| cupric reductase activity | STEAP3,STEAP2 |
Interacting Protein
STEAP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STEAP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of STEAP4.
AKT2
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References
- Grunewald, TGP; Bach, H; et al. The STEAP protein family: Versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions. BIOLOGY OF THE CELL 104:641-657(2012).
- Tanaka, Y; Matsumoto, I; et al. Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis. MODERN RHEUMATOLOGY 22:128-136(2012).
