STAU1
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Official Full Name
staufen, RNA binding protein, homolog 1 (Drosophila) -
Overview
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5UTR. -
Synonyms
STAU1;staufen, RNA binding protein, homolog 1 (Drosophila);STAU, staufen (Drosophila, RNA binding protein) , staufen, RNA binding protein (Drosophila);double-stranded RNA-binding protein Staufen homolog 1;Double stranded RNA binding protein Staufen homolog 1;Double stranded RNA binding protein Staufen homolog;FLJ25010;MGC124588;STAU;STAU1_HUMAN;staufen;Staufen RNA binding protein (Drosophila);Staufen RNA binding protein homolog 1;OTTHUMP00000031233;OTTHUMP00000031234;OTTHUMP00000031235;OTTHUMP00000031236;OTTHUMP00000031238;OTTHUMP00000031239
Recombinant Proteins
- Zebrafish
- Chicken
- Human
- Rhesus macaque
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- Non
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
STAU1 involved in several pathways and played different roles in them. We selected most pathways STAU1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with STAU1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
STAU1 has several biochemical functions, for example, double-stranded RNA binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAU1 itself. We selected most functions STAU1 had, and list some proteins which have the same functions with STAU1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MIS12,SUMO2,LIN9,SMARCE1,AKAP12,ZNF511,DNMT3A,KCNA1,ADCK5,CBFB |
| protein phosphatase 1 binding | PPP1R15A,PHACTR4,PHACTR3,PAWR,PHACTR3A,PHACTR1,PHACTR3B,PPP1R11,TCTEX1D4,LILRB2 |
| poly(A) RNA binding | CLTC,PPP1CC,PSMC1,MYH9,MKI67,SRSF9,MRPL2,HNRNPH2,RBM4B,HIST1H4I |
| double-stranded RNA binding | VIM,MYH4,IFIH1,SUPV3L1,OAS1,DHX36,AGO1,OASL2,PRKRIP1,ILF3 |
Interacting Protein
STAU1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAU1 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAU1.
UPF1;NS;RPLP0;NCL;RPS6;DHX9
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