STAT5B

  • Official Full Name

    Signal Transducer And Activator Of Transcription 5B
  • Overview

    The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL).
  • Synonyms

    STAT5B;signal transducer and activator of transcription 5B;STAT5;OTTHUMP00000198374;transcription factor STAT5B

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Rat
  • Chicken
  • Cynomolgus
  • Human/Mouse/Rat
  • Sf9 Insect Cell
  • E.coli
  • Mammalian Cell
  • Human Cells
  • HEK293
  • Mammalian cells
  • HEK293T
  • GST
  • His
  • His&T7
  • His&MBP
  • Non
  • His&Fc&Avi
  • Myc&DDK
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
STAT5B-74H Recombinant Human STAT5B, GST-tagged Sf9 Insect Cell Human GST
STAT5B-2998H Recombinant Human STAT5B, GST-tagged E.coli Human GST N-term-351aa
STAT5B-1183Z Recombinant Zebrafish STAT5B Mammalian Cell Zebrafish His
STAT5B-16112M Recombinant Mouse STAT5B Protein Mammalian Cell Mouse His
STAT5B-1851H Recombinant Human STAT5B protein, His & T7-tagged E.coli Human His&T7 Ala497~Ser749
STAT5B-197H Recombinant Human STAT5B, His-tagged E.coli Human His 1-321 a.a.
STAT5B-343H Recombinant Human STAT5B protein, His/MBP-tagged E.coli Human His&MBP 383-572 aa
STAT5B-5780R Recombinant Rat STAT5B Protein Mammalian Cell Rat His
STAT5B-6343C Recombinant Chicken STAT5B Mammalian Cell Chicken His
STAT5B-982C Recombinant Cynomolgus STAT5B Protein, His-tagged Mammalian Cell Cynomolgus His
STAT5B-1709HCL Recombinant Human STAT5B cell lysate Human Non
STAT5B-151H Recombinant Human STAT5B Protein, His-tagged Human Cells Human His
STAT5B-2118H Recombinant Human STAT5B Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
STAT5B-2118H-B Recombinant Human STAT5B Protein Pre-coupled Magnetic Beads HEK293 Human
STAT5B-2838H Recombinant Human STAT5B Protein, His-tagged E.coli Human/Mouse/Rat His Ala497-Ser749
STAT5B-2902H Recombinant Human STAT5B Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
STAT5B-325HFL Recombinant Full Length Human STAT5B Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
STAT5B-345H Recombinant Human STAT5B Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
STAT5B-5439R Recombinant Rat STAT5B Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
STAT5B-5439R-B Recombinant Rat STAT5B Protein Pre-coupled Magnetic Beads HEK293 Rat
Stat5b-6173M Recombinant Mouse Stat5b Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
STAT5B-6366H Recombinant Human STAT5B Protein (Met1-Thr321), C-His tagged E.coli Human His Met1-Thr321
STAT5B-6367H Recombinant Human STAT5B Protein (Met1-Thr351), N-His tagged E.coli Human His Met1-Thr351
STAT5B-725C Recombinant Cynomolgus Monkey STAT5B Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus His&Fc&Avi
STAT5B-725C-B Recombinant Cynomolgus Monkey STAT5B Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
STAT5B-8788M Recombinant Mouse STAT5B Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
STAT5B-8788M-B Recombinant Mouse STAT5B Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    STAT5B involved in several pathways and played different roles in them. We selected most pathways STAT5B participated on our site, such as ErbB signaling pathway,Chemokine signaling pathway,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chronic myeloid leukemia BCL2L1,SMAD3,MAP2K2,CDK6,HDAC2,PIK3R2,BAD,RB1,IKBKB,SHC4
    Viral carcinogenesis ACTN3,CCNE2,HDAC2,HIST3H2BB-PS,MAPK3,CCND2,PIK3CB,HIST1H2BJ,GTF2H4,STAT5A
    HTLV-I infection RELA,POLD4,ANAPC11,GPS2,ATM,IL6,IL15,MAPK8,CANX,WNT6
    Chemokine signaling pathway HRAS,ELMO1,GNAI1,XCR1,PRKACA,CCL3L3,JAK3,CCL21B,XCL1,VAV2
    Jak-STAT signaling pathway SOCS7,HRASB,IL22RA1,BCL2,IL20,IL-15RA,LEP,MTOR,AKT1,IL3RA
    ErbB signaling pathway MAPK3,MAPK9,RAF1,NCK2A,SHC2,PIK3R1,PAK2,PIK3CB,ERBB4,PAK4
    Hepatitis B CXCL8,TICAM2,FASLG,CCNE2,IKBKE,IFNB1,TLR4,CASP12,RELA,NFATC1
    Measles TLR2,IFNA1,Cd209g,Ifna15,NFKBIB,IFNA5,EIF2AK1,CD3E; CD3D,PIK3CG,IL2RB
    Prolactin signaling pathway PRLR,HRAS,SOCS4,PIK3CG,SOCS3,SOCS6,GALT,NEK3,MAP2K1,NFKB1

    Protein Function

    STAT5B has several biochemical functions, for example, DNA binding,chromatin binding,glucocorticoid receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT5B itself. We selected most functions STAT5B had, and list some proteins which have the same functions with STAT5B. You can find most of the proteins on our site.

    Function Related Protein
    chromatin binding JDP2,SMC1AL,NKX6,EOMES,UBTF,SOX9,NOC3L,RUNX2,JUN,NFKB1
    signal transducer activity NPFFR1L1,PTGER1C,GNAS,AGTR1B,MIER1A,OLFR507,OPN4A,V2RH7,IKBKG,GNB4
    protein binding VPS35,MPDZ,ESR2,TH1L,BMPR1B,CEP57L1,CTSL1,ITM2C,OSBPL2,NDRG4
    transcription factor activity, sequence-specific DNA binding GLI2,MEF2C,GATAD2AB,TBP,T,TRPS1,TFAP2B,HIVEP2A,E2F8,SOX32
    DNA binding TBPL1,MAFGA,POLR2EB,CREBZF,ZNF576.2,XRCC6,ZNF511,NR0B1,GTF2F1,NANOG
    protein dimerization activity HER1,BHLHA15,MESPBB,MESPBA,NUP210,MXI1,HER9,STAT3,ZBED1,ASCL5
    glucocorticoid receptor binding CEBPB,YWHAH,ETS2,FKBP4,NRIP1,NR4A2,GRIP1,EP300,STAT3

    Interacting Protein

    STAT5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT5B here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT5B.

    NMI;VCAM1;STAP2

    STAT5B Related Signal Pathway

    Resources

    Gene Families

    Cytokines

    References

    • Zhang, Q; Wang, HY; et al. Cutaneous T Cell Lymphoma Expresses Immunosuppressive CD80 (B7-1) Cell Surface Protein in a STAT5-Dependent Manner. JOURNAL OF IMMUNOLOGY 192:2913-2919(2014).
    • Atkinson, TP; et al. Immune deficiency and autoimmunity. CURRENT OPINION IN RHEUMATOLOGY 24:515-521(2012).

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