STARD5
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Official Full Name
StAR-related lipid transfer (START) domain containing 5 -
Overview
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g.,;SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and;SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and;uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute;regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid;STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002 (PubMed 12011452)). -
Synonyms
STARD5;StAR-related lipid transfer (START) domain containing 5;START domain containing 5;stAR-related lipid transfer protein 5;MGC10327;StAR related lipid transfer protein 5;START domain containing protein 5;START domain-containing protein 5
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
STARD5 involved in several pathways and played different roles in them. We selected most pathways STARD5 participated on our site, such as Metabolism,Metabolism of lipids and lipoproteins,Metabolism of steroid hormones and vitamin D, which may be useful for your reference. Also, other proteins which involved in the same pathway with STARD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of lipids and lipoproteins | MED15,CYP4F22,ANKRD1,CYP8B2,ARSF,SLC27A5,MED29,FA2H,SREBF2,GLTP |
| Metabolism | SLC25A20,PPP1R2,HELZ2,PCBD1,OXSR1,CIAPIN1,SLC44A5B,DTYMK,SLC25A10,ADA |
| Metabolism of steroid hormones and vitamin D | AKR1B15,CYP24A1,PPP1R2,CYP2R1,GC,CYP27B1,HSD17B11 |
Protein Function
STARD5 has several biochemical functions, for example, bile acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STARD5 itself. We selected most functions STARD5 had, and list some proteins which have the same functions with STARD5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| bile acid binding | PYGL,AKR1C21,NR1H4,PLA2G1B,FABP6,AKR1C2,FABP1,FABP10A |
Interacting Protein
STARD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STARD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of STARD5.
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References
- Rodriguez-Agudo, D; Ren, S; et al. Human StarD5, a cytosolic StAR-related lipid binding protein. JOURNAL OF LIPID RESEARCH 46:1615-1623(2005).
