STAM2
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Official Full Name
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 -
Overview
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. -
Synonyms
STAM2;signal transducing adaptor molecule (SH3 domain and ITAM motif) 2;signal transducing adapter molecule 2;Hbp;HSE1 homolog (S. cerevisiae);DKFZp564C047;Hrs-binding protein;Signal transducing adaptor molecule 2A;Signal transducing adaptor molecule 2B;Signal transducing adaptor molecule;STAM like protein containing SH3 and ITAM domains 2;STAM-2;STAM2_HUMAN;STAM2A;STAM2B;HSE1 homolog;OTTHUMP00000162711;STAM-like protein containing SH3 and ITAM domains 2
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- His&T7
- His&GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
STAM2 involved in several pathways and played different roles in them. We selected most pathways STAM2 participated on our site, such as EGFR downregulation,Endocytosis,Endosomal Sorting Complex Required For Transport (ESCRT), which may be useful for your reference. Also, other proteins which involved in the same pathway with STAM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | CNTFR,SOCS6,GM13305,THPO,IFNG,MTOR,PIAS4B,SOCS9,SOCS5,AKT1 |
| IL2-mediated signaling events | CISH,DOK2,IKZF3 |
| Endocytosis | CCDC53,CCR5,PLD1A,RNF41,GRK7A,VPS26A,DNM1A,CAPZA1B,BIN1B,CHMP4C |
| Endosomal Sorting Complex Required For Transport (ESCRT) | CHMP4B,VPS37A,CHMP4C,SNF8 |
| Signal Transduction | IRBP,RPE65B,APOA4B.1,ROR2,RGS4,ASH2L,FABP11A,FGD4,CCDC88C,BCL9 |
| Membrane Trafficking | CNO,SEC22C,PUM1,BLOC1S4,SEC23IP,EXOC6,MYO6A,SH3D19,NAPG,BLOC1S6 |
| EGFR downregulation | AP2B1,SPRY2,AP2S1,AP2M1,AP2A1,AP2A2,PTPRK,SPRY1 |
| IL-7 Signaling Pathway | IRF1B,MUC1 |
Protein Function
STAM2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAM2 itself. We selected most functions STAM2 had, and list some proteins which have the same functions with STAM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | COG1,IKZF1,FTCD,TAOK1,DDX6,TMEM51,LMX1B,HSD3B7,CXXC5,SLC30A3 |
Interacting Protein
STAM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAM2.
LCP2;DAZAP2;STAMBP;VPS37C;TIMM8A;RIN1
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References
- Dzombeta, T; Kapuralin, K; et al. Immunohistochemical Expression of STAM2 in Gastrointestinal Stromal Tumors. ANTICANCER RESEARCH 34:2291-2296(2014).
- Curlin, M; Lucic, V; et al. Splice variant of mouse Stam2 mRNA in nervous and muscle tissue contains additional. CROATIAN MEDICAL JOURNAL 47:16-24(2006).
