STAG2
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Official Full Name
stromal antigen 2 -
Overview
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. -
Synonyms
STAG2;stromal antigen 2;cohesin subunit SA-2;SA 2;SCC3B;SCC3 homolog 2;SA2;SA-2;bA517O1.1;FLJ25871;DKFZp686P168;DKFZp781H1753
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| STAG2-2987H | Recombinant Human STAG2, GST-tagged | E.coli | Human | GST | 1046-1171aa | |
| STAG2-2438H | Recombinant Human STAG2 protein, His-tagged | E.coli | Human | His | 1047-1172 aa | |
| STAG2-16090M | Recombinant Mouse STAG2 Protein | Mammalian Cell | Mouse | His |
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| STAG2-2740H | Recombinant Human STAG2 Protein, His-tagged | E.coli | Human | His | Met1-Leu268 |
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| STAG2-8772M | Recombinant Mouse STAG2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| STAG2-8772M-B | Recombinant Mouse STAG2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
STAG2 involved in several pathways and played different roles in them. We selected most pathways STAG2 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Cohesin Loading onto Chromatin, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Meiosis | POT1,FKBP6,MSH5,DMC1,TINF2,PSMC3IP,DIDO1,SUN1,ACD,SPO11 |
| Establishment of Sister Chromatid Cohesion | PDS5A,STAG1,ESCO2,CDCA5,ESCO1,PDS5B,WAPAL |
| Cell Cycle, Mitotic | PIANP,ESCO2,NCAPH2,GINS3,SPC25,NDEL1B,CDKN1B,SETA,GINS4,CKS1B |
| M Phase | NDEL1A,CDCA5,GORASP1,CENPC1,STAG1,CTDNEP1A,TMEM188,CENPI,NEK9,SPDL1 |
| Meiotic synapsis | SYNE1,TINF2,SYCP1,SYNE2,DIDO1,ACD,STAG1,SYCE1,TERF2IP,POT1 |
| Cohesin Loading onto Chromatin | STAG1,NIPBLB,PDS5B,NIPBL,MAU2,NIPBLA,WAPAL,PDS5A |
| Cell cycle | RAD21B,ORC4L,SMAD3B,MCM8,PLK1,CDC20,RB1,SDCCAG8,MDM2,SMAD3 |
Protein Function
STAG2 has several biochemical functions, for example, chromatin binding,protein binding,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAG2 itself. We selected most functions STAG2 had, and list some proteins which have the same functions with STAG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | MEIS1,TWIST2,ATF5,RBPJ,HDGFRP2,TOP2A,CCDC111,HMGXB4A,RNF2,DMRT1 |
| protein binding | STK38,DUSP1,ATG16L1,CYFIP1,HJURP,EIF4EA,PYURF,PPM1A,KNDC1,C10orf62 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | NKX2,SLAMF7,AIRE,MAFB,MYF6,ELF5,MAFA,BARHL1A,BARHL2,IRF2 |
Interacting Protein
STAG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAG2.
SMC3;RAD21;SMC1A
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