ST13
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Official Full Name
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -
Overview
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70;and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which;requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated;in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene. -
Synonyms
ST13;suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein);hsc70-interacting protein;FAM10A1;HIP;HSPABP1;P48;progesterone receptor associated p48 protein;SNC6;Hsp70-interacting protein;aging-associated protein 2;putativ
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ST13 involved in several pathways and played different roles in them. We selected most pathways ST13 participated on our site, such as Cellular response to heat stress,Cellular responses to stress,Regulation of HSF1-mediated heat shock response, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular responses to stress | LAMTOR2,MOV10,UVRAG,CBX8B,SCMH1,BMI1A,EP400,HIST1H1E,CBX4,TINF2 |
| Regulation of HSF1-mediated heat shock response | RPS19BP1,HSPH1,DNAJC7,HSPA7,HSPA13,DNAJC2,KIAA1967,HSPA14,BAG5,BAG3 |
| Cellular response to heat stress | C11orf73,BAG5,NUPL2,HSPA13,NUP50,KIAA1967,DPF1,NUP35,HSPA7,HSPA14 |
Protein Function
ST13 has several biochemical functions, for example, Hsp70 protein binding,chaperone binding,dATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ST13 itself. We selected most functions ST13 had, and list some proteins which have the same functions with ST13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | ABCC2,KPNB1,PRKAR2B,DRD3,ARRB2,GABRR3,MYH9,ETV6,HSPA5,RXRA |
| dATP binding | ERCC3,HSP90AB1 |
| chaperone binding | HES1,BAK1,PARK2,HSPA5,BAG1,DNAJB5,HSPE1,FGB,TIMM10,SYVN1 |
| unfolded protein binding | DNAJB5,PDRG1,HTRA2,HSP104,NAP1L4,HSPA6,GRPEL1,DNAJA2L,DNAJA3A,TMEM67 |
| protein binding | PEX6,CHD1,ENTPD5,KIF9,UPF1,F12,DYSFIP1,ITGB1BP3,CTAGE5,CXorf48 |
| protein complex binding | ERCC8,PTCH1,PCSK2,FBN1,TRADD,TG,DRD1,VHLL,NFKBIA,CDH2 |
| Hsp70 protein binding | C11orf73,MVD,STUB1,PPID,DNAJC2,METTL21A,DNAJB2,DNAJA1,PACRG,CDK1 |
| identical protein binding | EPHA4,HGF,HCFC1,IAPP,BNIP3L,BCL2L1,C1QTNF2,DYNLT1F,APAF1,MDM2 |
| protein binding, bridging | NCK1,CBX5,BFAR,FRMD4A,CAV2,FKBP4,CNTLN,SPRR1B,FSCN2,SH2D1B |
Interacting Protein
ST13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST13 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST13.
BAG1;APOE;NOS3;PSEN1;TNF;NME2;GABARAPL2;PCBD1;IKBKE;TNFRSF14;PINX1;MAP3K3;PRKAB1
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References
- Sugiyama, T; Sakaguchi, T; et al. Electron Microscopy and X-ray Analysis of Cr-Containing Precipitates Synthesized by Newly Isolated Actinobacterium, Flexivirga alba ST13(T). INDIAN JOURNAL OF MICROBIOLOGY 54:358-360(2014).
- AL Assaf, C; Lierman, E; et al. Screening of JAK2 V617F and MPL W515 K/L negative essential thrombocythaemia patients for mutations in SESN2, DNAJC17, ST13, TOP1MT, and NTRK1. BRITISH JOURNAL OF HAEMATOLOGY 165:734-737(2014).
