SSTR3
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Official Full Name
somatostatin receptor 3 -
Overview
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins.The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner.SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets.SSTR3 is functionally coupled to adenylyl cyclase. -
Synonyms
SSTR3;somatostatin receptor 3;somatostatin receptor type 3;OTTHUMP00000028737;Smstr3;Somatostatin receptor subtype 3;SS3R;SSR28;Sst3;SSTR 3;SS3-R;SS-3-R;SSR-28
Recombinant Proteins
- Mouse
- Chicken
- Rat
- Human
- Mus musculus
- Mammalian Cell
- E.coli expression system
- HEK293
- His
- His&Fc&Avi
Involved Pathway
SSTR3 involved in several pathways and played different roles in them. We selected most pathways SSTR3 participated on our site, such as Assembly of the primary cilium,BBSome-mediated cargo-targeting to cilium,Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with SSTR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | OPN1SW1,KISS1,CHRM2,ADCYAP1R1,ADORA1,DRD2,LPAR1,LPAR2A,GPRC6A,TAC1 |
| BBSome-mediated cargo-targeting to cilium | RAB3IP,BBS12,CCT5,TTC8,BBS7,CCT8,BBS5,BBS10,LZTFL1,SETD6 |
| Cargo trafficking to the periciliary membrane | ARL3,CCT5,BBS4,EXOC6,BBS10,SETD6,BBS1,BBS7,TCP1,PKD1 |
| G alpha (i) signalling events | CCR1,ADRA2B,OXGR1,RLN3,ADRA2C,S1PR5B,CXCR7B,CNR1,OPN1SW1,TAS2R7 |
| GPCRs, Class A Rhodopsin-like | GPR6,GPR63,OPN1SW,GPR75,LTB4R,SSTR2,NMUR1,GPR20,CCR7,HRH3 |
| GPCR ligand binding | GPR120,PRLH,EDN2,PTHLHA,CALCRL,CCR1,RGR,GPR65,FFAR3,LTB4R |
| Class A/1 (Rhodopsin-like receptors) | EDNRAB,PENK,NMUR1,EDN1,POMCB,S1PR5B,GPR18,CHRM3,HCRT,S1PR3 |
| Assembly of the primary cilium | NINL,TCTEX1D2,BBS10,TTC30A1,TCP1,MAPRE1,CDK5RAP2,PROL1,BBS4,KIF3A |
Protein Function
SSTR3 has several biochemical functions, for example, protein binding,receptor binding,somatostatin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SSTR3 itself. We selected most functions SSTR3 had, and list some proteins which have the same functions with SSTR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | ARPP19A,WNT4A,TGFB2,LRP6,Artn,LBP,GRP,SMARCD1,EHHADH,FGF1B |
| protein binding | C1orf116,PAM16,LONRF3,FZD10,PGBD1,VPS8,EPB41,MED11,PFKFB1,SNX19 |
| somatostatin receptor activity | SSTR2,SSTR1,SSTR4,SSTR5 |
Interacting Protein
SSTR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SSTR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SSTR3.
SSTR2;MPDZ;Mpdz;HSPA1A;TJP1;MAGI3;MPP5;GOPC;TJP2
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References
- Elston, MS; Meyer-Rochow, GY; et al. Increased SSTR2A and SSTR3 expression in succinate dehydrogenase-deficient pheochromocytomas and paragangliomas. HUMAN PATHOLOGY 46:390-396(2015).
- Lambertini, C; Barzaghi-Rinaudo, P; et al. Evaluation of somatostatin receptor subtype expression in human neuroendocrine tumors using two sets of new monoclonal antibodies. REGULATORY PEPTIDES 187:35-41(2013).
