SSTR1
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Official Full Name
somatostatin receptor 1 -
Overview
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach. -
Synonyms
SSTR1;somatostatin receptor 1;somatostatin receptor type 1;G-protein coupled receptor;SS1R;SS1-R;SRIF-2;SS-1-R
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Dog
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
SSTR1 involved in several pathways and played different roles in them. We selected most pathways SSTR1 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SSTR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peptide ligand-binding receptors | EDN2,GPR77,RLN3,CCL35.2,PROK1,SSTR5,NTS,QRFP,RLN3A,PYY |
| GPCRs, Class A Rhodopsin-like | CYSLTR1,SSTR4,GPR68,CX3CR1,NPFFR2,CCBP2,GPR32,CNR2,CCR3,GPR17 |
| GPCR downstream signaling | FPR-RS3,KALRN,OR52J3,SST1.1,TAAR1,PROK1,GCGA,PENKA,RHOGA,ARHGEF18A |
| Neuroactive ligand-receptor interaction | AGTR2,NTSR2,TAAR6,DRD2B,VIPR1B,BDKRB2,CHRNB2,MC5RB,P2RX3B,TRHR |
| Class A/1 (Rhodopsin-like receptors) | EDNRB,SSTR5,NPSR1,GPR65,CNR1,RLN2,FPR-RS6,CCL35.1,CNR2,CXCR6 |
| Peptide GPCRs | CXCR6,CX3CR1,TAC4,SSTR4,SSTR5 |
| G alpha (i) signalling events | CCL35.2,PTGDR2,SSTR4,S1PR1,PNOCB,APLN,OPN1SW1,LPAR2B,RLN3A,ADORA1 |
| GPCR ligand binding | PROK1,GPR55A,ADM2,CASR,GRP,SST1.1,RLN3A,TAS2R7,CCK,RXFP2 |
Protein Function
SSTR1 has several biochemical functions, for example, neuropeptide binding,somatostatin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SSTR1 itself. We selected most functions SSTR1 had, and list some proteins which have the same functions with SSTR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| somatostatin receptor activity | SSTR2,SSTR4,SSTR3,SSTR5 |
| neuropeptide binding | SSTR5,MRGPRX2,OPRL1,NPY8BR,MC4R,OPRD1B,GALR1,OPRM1,ADCYAP1R1,NPBWR2 |
Interacting Protein
SSTR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SSTR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SSTR1.
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References
- Elston, MS; Meyer-Rochow, GY; et al. Increased SSTR2A and SSTR3 expression in succinate dehydrogenase-deficient pheochromocytomas and paragangliomas. HUMAN PATHOLOGY 46:390-396(2015).
- Lambertini, C; Barzaghi-Rinaudo, P; et al. Evaluation of somatostatin receptor subtype expression in human neuroendocrine tumors using two sets of new monoclonal antibodies. REGULATORY PEPTIDES 187:35-41(2013).
