SRSF5
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Official Full Name
serine/arginine-rich splicing factor 5 -
Overview
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
HRS;SFRS5;SRP40;serine/arginine-rich splicing factor 5;SR splicing factor 5;delayed-early protein HRS;pre-mRNA-splicing factor SRP40;splicing factor, arginine/serine-rich 5;SRSF5;serine/arginine-rich splicing factor 5
Recombinant Proteins
- Human
- Chicken
- Rat
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SFRS5-102H | Recombinant Human SFRS5, GST-tagged | Wheat Germ | Human | GST | 1 a.a. - 272 a.a. |
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| SRSF5-2861C | Recombinant Chicken SRSF5 | Mammalian Cell | Chicken | His |
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| SRSF5-5748R | Recombinant Rat SRSF5 Protein | Mammalian Cell | Rat | His |
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| SRSF5-1903HCL | Recombinant Human SFRS5 293 Cell Lysate | HEK293 | Human | Non |
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| SRSF5-468HF | Recombinant Full Length Human SRSF5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 272 amino acids |
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| SRSF5-5407R | Recombinant Rat SRSF5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SRSF5-5407R-B | Recombinant Rat SRSF5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
SRSF5 involved in several pathways and played different roles in them. We selected most pathways SRSF5 participated on our site, such as Spliceosome,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRSF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | IFNA3,HLA-DMA,SRSF2,MYD88,SFRS9,HLA-DPA1,MHC1UXA2,ARNTL1A,SRSF1B,C3A.2 |
| Spliceosome | CDC5L,HNRNPA1,EFTUD2,CDC40,SMX5,PRPF18,XAB2,SRSF1B,THOC2,PUF60 |
Protein Function
SRSF5 has several biochemical functions, for example, RS domain binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRSF5 itself. We selected most functions SRSF5 had, and list some proteins which have the same functions with SRSF5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RS domain binding | LUC7L,SRSF12,SRSF10,SRSF1 |
| poly(A) RNA binding | UBA1,MRPS15,NOP2,ADAR,CDC40,GSPT2,RPL23A,ZCCHC11,EEF2,PCBP3 |
| nucleotide binding | U2SURP,MSI2,CAMK2D1,RBPMS2,STK38A,KIF3CB,GKUP,PPARGC1B,FGFR1A,GRK1A |
| protein binding | FCGR2C,ARF5,TMPRSS7,MSN,MCM4,ID3,HUWE1,ECE2,ACHE,THBD |
Interacting Protein
SRSF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRSF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRSF5.
ESR2;SRPK2;NR3C1;SF3A2;SMAD2;OLFM2;SNRPF;TNK2;RPS6KA1;MAPK14;MAPK6;treB;csgG;der;CD101;ssrna_ug
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References
- Robard, C; Daviau, A; et al. Phosphorylation status of the Kep1 protein alters its affinity for its protein binding partner alternative splicing factor ASF/SF2. BIOCHEMICAL JOURNAL 400:91-97(2006).
- Koizumi, J; Okamoto, Y; et al. The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). JOURNAL OF BIOLOGICAL CHEMISTRY 274:11125-11131(1999).
