SRD5A3
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Official Full Name
steroid 5 alpha-reductase 3 -
Overview
The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Iq. -
Synonyms
SRD5A3;steroid 5 alpha-reductase 3;probable polyprenol reductase;FLJ13352;SRD5A2L;SRD5A2L1;S5AR 3;SR type 3;3-oxo-5-alpha-steroid 4-dehydrogenase 3;CDG1P;CDG1Q;KRIZI
Recombinant Proteins
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- Human
- zebrafish
- Ailuropoda melanoleuca
- Mesocricetus auratus
- Mus musculus
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Xenopus laevis
- Mammalian Cell
- E.coli expression system
- HEK293
- His
- His&Fc&Avi
Involved Pathway
SRD5A3 involved in several pathways and played different roles in them. We selected most pathways SRD5A3 participated on our site, such as Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRD5A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Steroid hormone biosynthesis | SULT1E1,UGT1A7C,HSD11B1,HSD3B1,CYP21A1,UGT1A1,HSD17B6,HSD3B6,SULT2B1,SRD5A2B |
Protein Function
SRD5A3 has several biochemical functions, for example, 3-oxo-5-alpha-steroid 4-dehydrogenase activity,cholestenone 5-alpha-reductase activity,oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRD5A3 itself. We selected most functions SRD5A3 had, and list some proteins which have the same functions with SRD5A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cholestenone 5-alpha-reductase activity | SRD5A1,SRD5A2 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase activity | SRD5A1,PPP1R2,SRD5A2B,SRD5A2A,SRD5A2 |
| oxidoreductase activity | LEPREL1,ALDH2.2,CYP3A25,C1orf43,YWHAQB,FAXDC2,AKR1A1B,GULO,CYP2D26,KDM1B |
| oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | DHCR24,TM7SF2,LBR,BDH2 |
| oxidoreductase activity, acting on the CH-CH group of donors | GCDHA,ACOXL,TECRL2B,TM7SF2,SRD5A2B,TECRB,TECRL,GCDHB,PPP1R2,TECR |
Interacting Protein
SRD5A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRD5A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRD5A3.
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References
- Jardel, P; Debiais, C; et al. Ductal carcinoma of the prostate shows a different immunophenotype from high grade acinar cancer. HISTOPATHOLOGY 63:57-63(2013).
- Seo, YK; Mirkheshti, N; et al. SULT2B1b Sulfotransferase: Induction by Vitamin D Receptor and Reduced Expression in Prostate Cancer. MOLECULAR ENDOCRINOLOGY 27:925-939(2013).
