SRD5A1
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Official Full Name
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) -
Overview
Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306). -
Synonyms
SRD5A1;steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1);3-oxo-5-alpha-steroid 4-dehydrogenase 1;S5AR;SR type 1;3 oxo 5 alpha steroid 4 dehydrogenase 1;3 Oxo 5 alpha steroid delta 4 dehydrogenase alpha 1;3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1,5-alpha reductase;5 alpha reductase;S5A1_HUMAN;S5AR 1;SRD5A 1;Steroid 5 alpha reductase 1;Steroid 5 alpha reductase alpha polypeptide 1 (3 oxo 5 alpha steroid delta 4 dehydrogenase alpha 1);Steroid 5 alpha reductase alpha polypeptide 1;Steroid 5 alpha reductase type I;Steroid 5-alpha-reductase 1;5-alpha reductase;steroid 5-alpha-reductase type I;3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Cynomolgus
- Bovine
- Mus musculus
- Macaca fascicularis
- E.coli
- Mammalian Cell
- Wheat Germ
- E.coli expression system
- In Vitro Cell Free System
- HEK293
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
SRD5A1 involved in several pathways and played different roles in them. We selected most pathways SRD5A1 participated on our site, such as Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRD5A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Steroid hormone biosynthesis | HSD17B3,CYP2C55,CYP3A41B,UGT1A2,UGT1A9,HSD3B2,HSD17B6,HSD3B6,UGT1A1,H2-KE6 |
Protein Function
SRD5A1 has several biochemical functions, for example, 3-oxo-5-alpha-steroid 4-dehydrogenase activity,cholestenone 5-alpha-reductase activity,electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRD5A1 itself. We selected most functions SRD5A1 had, and list some proteins which have the same functions with SRD5A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| electron carrier activity | IDO1,AKR1B1,HSD17B6,AKR1C4,ACOX3,ACADL,ACADVL,DHRS3,COX5A,NCF2 |
| cholestenone 5-alpha-reductase activity | SRD5A3,SRD5A2 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase activity | SRD5A2B,SRD5A3,SRD5A2A,PPP1R2,SRD5A2 |
Interacting Protein
SRD5A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRD5A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRD5A1.
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References
- Seo, YK; Mirkheshti, N; et al. SULT2B1b Sulfotransferase: Induction by Vitamin D Receptor and Reduced Expression in Prostate Cancer. MOLECULAR ENDOCRINOLOGY 27:925-939(2013).
