SPTBN1

  • Official Full Name

    spectrin, beta, non-erythrocytic 1

  • Overview

    Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    SPTBN1;spectrin, beta, non-erythrocytic 1;spectrin beta chain, brain 1;beta-fodrin;beta-G spectrin;beta-spectrin 2;beta-II spectrin;beta-spectrin II;fodrin beta chain;embryonic liver beta-fodrin;spectrin, non-erythroid beta chain 1;ELF;SPTB2

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • Cynomolgus
  • E.coli
  • Mammalian Cells
  • C-His
  • HEK293
  • His
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SPTBN1-30885TH Recombinant Human SPTBN1, His-tagged E.coli Human His 280-692 a.a.
SPTBN1-4298C Recombinant Chicken SPTBN1 Mammalian Cells Chicken His
SPTBN1-4456R Recombinant Rhesus monkey SPTBN1 Protein, His-tagged Mammalian Cells Rhesus macaque His
SPTBN1-1639C Recombinant Cynomolgus SPTBN1 protein, His-tagged C-His Cynomolgus Phe17-Gln318
SPTBN1-200HCL Recombinant Human SPTBN1 cell lysate, Myc/DDK-tagged HEK293 Human Myc&DDK
SPTBN1-4272R Recombinant Rhesus Macaque SPTBN1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
SPTBN1-4272R-B Recombinant Rhesus Macaque SPTBN1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    SPTBN1 involved in several pathways and played different roles in them. We selected most pathways SPTBN1 participated on our site, such as ARMS-mediated activation,Axon guidance,Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTBN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell-Cell communication CDH12,JUP,F11R.2,FBLIM1,CDH13,CLDN23,CDH3,CDH9,CLDN7,CDH24
    Cytokine Signaling in Immune system KBTBD7,CSH1,KLB,IRF4,SPRED3,CSF2,GBP2,DUSP2,EIF4G2,CSHL1
    DAP12 signaling WDR83,DUSP1,PEBP1,DUSP6,AGO1,SPRED2,LCP2A,SPTB,DAB2IPB,CSF2RA
    ARMS-mediated activation PEBP1,FGFR1B,KIDINS220B,DUSP7,FGF8B,PSMD5,DUSP10,SPNA1,NRG4,FGF18B
    Downstream signal transduction DUSP9,AGO2,SPRED2,DAB2IPB,TRAT1,PHB,FGF10B,DUSP7,PAQR3A,AGO1
    Axon guidance MYL9,NCK2,EFNA1,ST8SIA2,CAP2,RNF8,CLASP1,PTPRA,RND1L,LIMK1
    DAP12 interactions CSF2RB,PHB,PRKAR1AA,SPNA2,PEA15,SIGLEC15,CD300E,PAQR3B,LAMTOR2,SIGLEC14
    Developmental Biology EPHB4A,INSM1B,EFNB3,CDH4,WDR83,LGI4,PLXNC1,KLB,LGI1B,RGMB

    Protein Function

    SPTBN1 has several biochemical functions, for example, GTPase binding,actin binding,ankyrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTBN1 itself. We selected most functions SPTBN1 had, and list some proteins which have the same functions with SPTBN1. You can find most of the proteins on our site.

    Function Related Protein
    actin binding ACTN3,PLECA,WASL,GMFG,SPTAN1,HDAC6,MICAL2,MAEA,EPB41L2,WASLB
    poly(A) RNA binding RPUSD2,MACF1,TIAL1,FAM133B,ISG20L2,RBM39,CIRBP,DAZAP1,RPS27.1,TXN
    phospholipid binding APOA2,PLEKHA3,BPIFC,SERPINB1A,VAMP2,ARHGAP44,APOEB,LPAR3,SNCA,OTC
    GTPase binding GNB3,AIMP1,STOML2,HSP90AA1,GM5506,GNB2,PTPRN,EPRS,MARCH5,GNB1
    structural constituent of cytoskeleton KRT5,KRT6B,SORBS3,TUBD1,TUBA1L,BFSP1,ATXN1,EPB42,TUBB1,NDC80
    protein binding TSGA10,NID2,UQCC2,DUSP5,CDCA8,SPAG5,SCP2,CYP1A1,MTRR,CCDC28A
    calmodulin binding EPB41,CAMSAP1,TJP1,DAPK1,SPTAN1,GM101,SPA17,MYO1C,KCNQ3,RASGRF2
    ankyrin binding KCTD6,RHAG,PTBP3,ATP1A1,KCNQ2,OBSCN,NRCAM,KCNJ11,SLC4A1,SLC8A1

    Interacting Protein

    SPTBN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTBN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTBN1.

    SPTA1;GRB2;CDC5L;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;spectrin_a1_a2_prot;SPTAN1

    Resources

    References

    • Lin, L; Yao, ZX; et al. Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC cAMP-response element-binding proteins ATF3 and CREB2. CARCINOGENESIS 35:2393-2403(2014).
    • Demiralp, DO; Haznedaroglu, IC; et al. Functional proteomic analysis of Ankaferd (R) Blood Stopper. TURKISH JOURNAL OF HEMATOLOGY 27:70-77(2010).

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