SPRY2
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Official Full Name
sprouty homolog 2 (Drosophila) -
Overview
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008] -
Synonyms
SPRY2;sprouty homolog 2 (Drosophila);hSPRY2;protein sprouty homolog 2;spry-2;sprouty 2
Recombinant Proteins
- Zebrafish
- Chicken
- Human
- Mouse
- Rat
- Mammalian Cell
- HEK293
- Mammalian cells
- E.coli
- HEK293T
- His
- Non
- Flag
- His&T7
- His&Fc&Avi
- Myc&DDK
- N-His&C-Myc
Involved Pathway
SPRY2 involved in several pathways and played different roles in them. We selected most pathways SPRY2 participated on our site, such as EGFR downregulation,EGFR1 Signaling Pathway,FGF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPRY2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FGF signaling pathway | SP8A,FGF24,BGLAP,EGR2A,TA,FGFRL1A,JUNBA,FGFRL1B,SOX32,PAK4 |
| MicroRNAs in cancer | SIRT1,APC,TP63,BCL2,MAP2K2,DDIT4,ABL1,Casp3,CCNE2,RPS6KA5 |
| Internalization of ErbB1 | STAMBP,ZFYVE28,FMNL3,RNF103-CHMP3 |
| EGFR downregulation | AP2A1,AP2M1,SPRY1,AP2B1,PTPRK,AP2S1,STAM2,AP2A2 |
| EGFR1 Signaling Pathway | USP6NL,DOK2,CEBPA,EEF1A1,GRB7,KRT8,RBBP7,CEACAM1,REPS1,KRT17 |
Protein Function
SPRY2 has several biochemical functions, for example, protein binding,protein kinase binding,protein serine/threonine kinase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPRY2 itself. We selected most functions SPRY2 had, and list some proteins which have the same functions with SPRY2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | HDAC4,PTEN,NPR1,PPP1R12A,PDCD10,PEBP1,MVP,FER,ACTA2,HIF1A |
| protein serine/threonine kinase inhibitor activity | SPRED2,CIB1,SPRED1,H2AFY |
| protein serine/threonine kinase activator activity | CALM3,CDK5R1,CALM2,CALM1,LTF,FAM20A,STRADA,IGF2,STK3,STK4 |
| protein binding | RFFL,SLC30A8,ZNF256,ZNF193,PFKFB2,SMURF1,NAT8,PFKM,RIPK4,PASK |
Interacting Protein
SPRY2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPRY2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPRY2.
CBL;OTX1
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References
- Peralvarez-Marin, A; Tae, H; et al. 3D Mapping of the SPRY2 Domain of Ryanodine Receptor 1 by Single-Particle Cryo-EM. PLOS ONE 6:-(2011).
- Tae, H; Wei, L; et al. The elusive role of the SPRY2 domain in RyR1. CHANNELS 5:148-160(2011).
