SPRED2
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Official Full Name
sprouty-related, EVH1 domain containing 2 -
Overview
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced;activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 (PubMed 15465815)). -
Synonyms
SPRED2;sprouty-related, EVH1 domain containing 2;sprouty-related, EVH1 domain-containing protein 2;C79158;FLJ21897;FLJ31917;MGC163164;Spred 2;Sprouty protein with EVH 1 domain 2 related sequence;sprouty related EVH1 domain containing 2;Sprouty related protein with EVH 1 domain 2;zgc:77284;OTTHUMP00000202294;OTTHUMP00000202297;OTTHUMP00000225519;sprouty protein with EVH-1 domain 2, related sequence;Spred-2
Recombinant Proteins
- Mouse
- Rhesus macaque
- Rat
- Human
- Mammalian Cell
- HEK293
- E.coli
- His
- Non
- His&T7
- His&Fc&Avi
Involved Pathway
SPRED2 involved in several pathways and played different roles in them. We selected most pathways SPRED2 participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPRED2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Downstream signaling of activated FGFR1 | AGO2,SPNA1,PEA15,PHB,SPTB,PEA15A,RASGEF1A,CNKSR1,PAQR3A,RASGRP4 |
| DAP12 interactions | NRG4,SPTBN2,IL17RD,FGF8B,CD300E,DAB2IPB,DUSP9,DUSP5,WDR83,PEBP1 |
| ARMS-mediated activation | EGF,CSK,NEFLB,FGF18B,HBEGF,PSMD14,RASGEF1A,NTF7,FGF20A,PEA15A |
| Developmental Biology | TCF4,SCN8A,CNKSR1,NRP2,PSPN,CAP2,LEFTY1,GDNF,KCNQ3,CEBPB |
| Cytokine Signaling in Immune system | RASGEF1A,PAQR3B,RASGRP4,KPNA4,KBTBD7,TNFSF13B,CASPB,WDR83,HLA-DQB2,EIF4E |
| Downstream signal transduction | RASGEF1A,PEBP1,GRB7,SPTA1,PAQR3A,AGO2,SPTB,PEA15,JAK1,FGF8B |
| DAP12 signaling | LCP2A,HBEGF,LAMTOR2,IL17RD,MARK3,NRG3,PAQR3A,PAQR3B,DUSP7,JAK1 |
| Axon guidance | JAK3,CNTN6,LRRC4,PAK4,ACTR2B,COL9A1,Ntng2,RGS3,NFATC2,KLB |
Protein Function
SPRED2 has several biochemical functions, for example, protein binding,protein kinase binding,protein serine/threonine kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPRED2 itself. We selected most functions SPRED2 had, and list some proteins which have the same functions with SPRED2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PTS,TNNT1,SOX14,DPYSL5,ARPC2,KIF14,NCALD,SYCE1,RBM12B,EBF1 |
| stem cell factor receptor binding | KITLGB,SPRED1,KITLGA,Kitl,KITLG |
| protein kinase binding | DNM1,YWHAZ,CAV2,THY1,BCL2L14,USF1,DOK7,PDPK1,PARN,CALM2 |
| protein serine/threonine kinase inhibitor activity | SPRY2,SPRED1,H2AFY,CIB1 |
Interacting Protein
SPRED2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPRED2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPRED2.
TOP3B;SPG21;ZDHHC17;CBL
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