SPR
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Official Full Name
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) -
Overview
This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. -
Synonyms
SPR;sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase);sepiapterin reductase;SDR38C1;short chain dehydrogenase/reductase family 38C;member 1;OTTHUMP00000160199;short chain dehydrogenase/reductase family 38C, member 1;SPRE_HUMAN
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- E. coli
- HEK293T
- GST
- His&GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SPR involved in several pathways and played different roles in them. We selected most pathways SPR participated on our site, such as Folate biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Folate biosynthesis | ALPI,ALP3,GCH1,SPRA,ALPI.1,MOCS2,GGH,PTS,QDPRB2,ALPP |
| Metabolic pathways | MGAT1A,CKMT2B,KYNU,NT5C3A,ALDOAB,PYGM,GALM,SC5D,PLCD1,EHHADH |
Protein Function
SPR has several biochemical functions, for example, NADP binding,aldo-keto reductase (NADP) activity,sepiapterin reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPR itself. We selected most functions SPR had, and list some proteins which have the same functions with SPR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADP binding | ASPDH,NOS1,H6PD,MTHFR,HMGCRA,GAPDHS,CAT,PGD,FMO3,ME1 |
| aldo-keto reductase (NADP) activity | KCNAB2,AKR1C6,AKR1C4,AKR1C3,AKR7A3,AKR1B10,MIOX,HSD3B5,KCNAB1,CYB5A |
| sepiapterin reductase activity | SPRB,SPRA |
Interacting Protein
SPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPR here. Most of them are supplied by our site. Hope this information will be useful for your research of SPR.
YWHAZ;midostaurin
Resources
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References
- Suherman; Morita, K; et al. Highly selective and sensitive detection of beta-agonists using a surface plasmon resonance sensor based on an alkanethiol monolayer functionalized on a Au surface. BIOSENSORS & BIOELECTRONICS 67:356-363(2015).
- Soler, M; Mesa-Antunez, P; et al. Highly sensitive dendrimer-based nanoplasmonic biosensor for drug allergy diagnosis. BIOSENSORS & BIOELECTRONICS 66:115-123(2015).
