SPPL2B
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Official Full Name
signal peptide peptidase like 2B -
Overview
This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
SPPL2B;signal peptide peptidase like 2B;IMP4;PSH4;PSL1;IMP-4;signal peptide peptidase-like 2B;SPP-like 2B;intramembrane protease 4;presenilin-like protein 1;presenilin homologous protein 4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SPPL2B-2622C | Recombinant Chicken SPPL2B | Mammalian Cell | Chicken | His |
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| SPPL2B-5721R | Recombinant Rat SPPL2B Protein | Mammalian Cell | Rat | His |
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| SPPL2B-1500HCL | Recombinant Human SPPL2B 293 Cell Lysate | HEK293 | Human | Non |
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| SPPL2B-5380R | Recombinant Rat SPPL2B Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SPPL2B-5380R-B | Recombinant Rat SPPL2B Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
SPPL2B involved in several pathways and played different roles in them. We selected most pathways SPPL2B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPPL2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SPPL2B has several biochemical functions, for example, aspartic endopeptidase activity, intramembrane cleaving,NOT aspartic endopeptidase activity, intramembrane cleaving,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPPL2B itself. We selected most functions SPPL2B had, and list some proteins which have the same functions with SPPL2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | TDG,CHKA,GCA,EIF2AK1,PLOD1,GZMA,NOS2,HOMER2,BNIP3,ADIPOQ |
| aspartic endopeptidase activity, intramembrane cleaving | SPPL3,HM13 |
| protein binding | PIN4,MAPK7,AHNAK2,PPP6C,ZNF460,STX7,Icosl,PUF60,MTTP,ACSF2 |
Interacting Protein
SPPL2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPPL2B here. Most of them are supplied by our site. Hope this information will be useful for your research of SPPL2B.
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