SPG11
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Official Full Name
spastic paraplegia 11 (autosomal recessive) -
Overview
The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SPG11;spastic paraplegia 11 (autosomal recessive);KIAA1840;spatacsin;FLJ21439;Colorectal carcinoma associated protein;Colorectal carcinoma-associated protein;DKFZp762B1512;Spastic paraplegia 11;Spastic paraplegia 11 protein;SPG 11;SPTCS_HUMAN
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SPG11-2914H | Recombinant Human SPG11, GST-tagged | E.coli | Human | GST | C-term-350aa | |
| SPG11-15873M | Recombinant Mouse SPG11 Protein | Mammalian Cell | Mouse | His |
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| SPG11-7712Z | Recombinant Zebrafish SPG11 | Mammalian Cell | Zebrafish | His |
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| SPG11-7800Z | Recombinant Zebrafish SPG11 | Mammalian Cell | Zebrafish | His |
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| SPG11-1681HCL | Recombinant Human SPG11 cell lysate | Human | Non |
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| SPG11-8640M | Recombinant Mouse SPG11 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SPG11-8640M-B | Recombinant Mouse SPG11 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SPG11 involved in several pathways and played different roles in them. We selected most pathways SPG11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPG11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SPG11 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPG11 itself. We selected most functions SPG11 had, and list some proteins which have the same functions with SPG11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NUDCD2,RRAS2,TOP3B,RHOB,SMCO4,ISYNA1,RASSF4,CANX,FAM32A,HSD17B10 |
Interacting Protein
SPG11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPG11 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPG11.
SERTAD3;hmsS;copA;tcaA1;CD247;Elavl1
Resources
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References
- Kuru, S; Yoshida, M; et al. Immunohistochemical localization of spatacsin in alpha-synucleinopathies. NEUROPATHOLOGY 34:135-139(2014).
- Murmu, RP; Martin, E; et al. Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia. MOLECULAR AND CELLULAR NEUROSCIENCE 47:191-202(2011).
