SPEN
-
Official Full Name
spen homolog, transcriptional regulator -
Overview
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. -
Synonyms
SPEN;spen homolog, transcriptional regulator (Drosophila);msx2-interacting protein;KIAA0929;MINT;RBM15C;SHARP;nuclear receptor transcription cofactor;SMART/HDAC1 associated repressor protein;S
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|
Involved Pathway
SPEN involved in several pathways and played different roles in them. We selected most pathways SPEN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPEN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SPEN has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SPEN itself. We selected most functions SPEN had, and list some proteins which have the same functions with SPEN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
SPEN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPEN here. Most of them are supplied by our site. Hope this information will be useful for your research of SPEN.
Resources
Related Services
Related Products
References
