SPANXC
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Official Full Name
SPANX family, member C -
Overview
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. -
Synonyms
SPANXC;SPANX family, member C;sperm protein associated with the nucleus on the X chromosome C;cancer/testis antigen family 11;member 3;CT11.3;CTp11;SPAN-Xc protein;cancer/testis antigen 11.3;nuclear-associated protein SPAN-Xc;cancer-testis-assoc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SPANXC-2897H | Recombinant Human SPANXC, GST-tagged | E.coli | Human | GST | 1-97aa | |
| SPANXC-621HCL | Recombinant Human SPANXC lysate | HEK293 | Human | Non |
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| SPANXC-2724H | Recombinant Human SPANXC Protein, His-tagged | E.coli | Human | His | Met1-Lys97 |
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Involved Pathway
SPANXC involved in several pathways and played different roles in them. We selected most pathways SPANXC participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPANXC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SPANXC has several biochemical functions, for example, molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPANXC itself. We selected most functions SPANXC had, and list some proteins which have the same functions with SPANXC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | TDPOZ5,RBFA,FAM209A,TMCC3,GM14436,ANKRD13A,GM239,SEBOX,OCSTAMP,PBDC1 |
| protein binding | POLD1,FBXL12,C16orf70,VPS37B,FAM49B,ITGAM,TRPV4,ZNF707,MRPL45,COMMD1 |
Interacting Protein
SPANXC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPANXC here. Most of them are supplied by our site. Hope this information will be useful for your research of SPANXC.
SETBP1
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References
- Kouprina, N; Lee, NCO; et al. Exclusion of the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy in HPCX1-linked families. GENES CHROMOSOMES & CANCER 51:933-948(2012).
- Hansen, MA; Nielsen, JE; et al. A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family. MOLECULAR REPRODUCTION AND DEVELOPMENT 75:219-229(2008).
