SPAG9
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Official Full Name
sperm associated antigen 9 -
Overview
This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] -
Synonyms
SPAG9;sperm associated antigen 9;JLP;CT89;HLC4;HLC6;JIP4;PHET;PIG6;HLC-6;JIP-4;C-Jun-amino-terminal kinase-interacting protein 4;sunday driver 1;Max-binding protein;sperm surface protein;lung cancer oncogene 4;JNK interacting protein;cancer/testis antigen 89;JNK/SAPK-associated protein;proliferation-inducing gene 6;protein highly expressed in testis;human lung cancer oncogene 6 protein;mitogen-activated protein kinase 8-interacting protein 4;c-Jun NH2-terminal kinase-associated leucine zipper protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SPAG9-2896H | Recombinant Human SPAG9, GST-tagged | E.coli | Human | GST | 199-273aa | |
| SPAG9-2505H | Recombinant Human SPAG9 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| SPAG9-3116H | Recombinant Human SPAG9 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| SPAG9-5322H | Recombinant Human SPAG9 protein, His&Myc-tagged | E.coli | Human | His&Myc | 408-534a.a. |
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Involved Pathway
SPAG9 involved in several pathways and played different roles in them. We selected most pathways SPAG9 participated on our site, such as Arf6 trafficking events,CDO in myogenesis,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPAG9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Myogenesis | BNIP2,CDON,CDH4,TCF12,MYOD1,TCF4,MYF6,BOC,TCF3A,MYOG |
| Developmental Biology | JAK1,KIF4A,COL4A4,MED16,SHB,SEMA3A,EZRA,MYF6,CRMP1,POU5F3 |
| Arf6 trafficking events | EXOC3,CPE,EXOC1,PTBP3,CLTC,CTNNA1,CHRM2,ADRB2,CTNND1,EDNRB |
| CDO in myogenesis | TCF3B,BNIP2,CDON,TCF3A,MYF6,TCF4,MYOG,CTNNA1,CTNNA2,MEF2AA |
Protein Function
SPAG9 has several biochemical functions, for example, JUN kinase binding,MAP-kinase scaffold activity,kinesin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPAG9 itself. We selected most functions SPAG9 had, and list some proteins which have the same functions with SPAG9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MAP-kinase scaffold activity | SPAG9A,JIP1,CD36,DUSP19,MAPK8IP2,KSR1,MAPK8IP3 |
| mitogen-activated protein kinase p38 binding | NFATC1,RPS6KA4,PRMT1,TAB1 |
| JUN kinase binding | GSTP1,SPAG9A,MAD2L2,PTK2,MAPK8IP3 |
| receptor signaling complex scaffold activity | CD3E,ROPN1B,NUP62,GRIP2A,SPAG9A,SHANK1,DEDD2,G3BP2,CD3G,MMS19 |
| protein binding | RACGAP1,C1orf21,TIA1,CPSF7,IL17RE,ALDH3B1,EGR2,DZIP1L,RABGAP1,COMMD6 |
| kinesin binding | KIFAP3,CD36,NEK6,GOLSYN,PRC1,ACTB,KIFAP3B,ATCAY,JIP1,ARPC2 |
Interacting Protein
SPAG9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPAG9 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPAG9.
ARF6;EXOC4;ARF1;NFKB1;Arf6;Plk1;EIF4A2
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References
- Agarwal, S; Parashar, D; et al. Sperm associated antigen 9 (SPAG9) expression and humoral response in benign and malignant salivary gland tumors. ONCOIMMUNOLOGY 3:-(2014).
- Yu, P; Yan, L; et al. Expression and Clinical Significance of Sperm-Associated Antigen 9 in Patients With Endometrial Carcinoma. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 22:87-93(2012).
