SPAG6
-
Official Full Name
sperm associated antigen 6 -
Overview
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. -
Synonyms
SPAG6;sperm associated antigen 6;sperm-associated antigen 6;axoneme central apparatus protein;pf16;Repro SA 1;PF16 protein homolog;Protein PF16 homolog;Repro-SA-1;SPAG6_HUMAN;Sperm flagellar protein;OTTHUMP00000019296;OTTHUMP00000019297
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SPAG6-2893H | Recombinant Human SPAG6, GST-tagged | E.coli | Human | GST | C-term-350aa | |
| SPAG6-427Z | Recombinant Zebrafish SPAG6 | Mammalian Cells | Zebrafish | His |
|
|
| SPAG6-4403C | Recombinant Chicken SPAG6 | Mammalian Cells | Chicken | His |
|
|
| SPAG6-1549HCL | Recombinant Human SPAG6 293 Cell Lysate | HEK293 | Human | Non |
|
|
| SPAG6-537H | Recombinant Human SPAG6 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
|
|
| Spag6-6071M | Recombinant Mouse Spag6 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
|
Involved Pathway
SPAG6 involved in several pathways and played different roles in them. We selected most pathways SPAG6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPAG6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SPAG6 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SPAG6 itself. We selected most functions SPAG6 had, and list some proteins which have the same functions with SPAG6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
SPAG6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPAG6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPAG6.
Resources
Related Services
Related Products
References
