SPACA1
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Official Full Name
sperm acrosome associated 1 -
Overview
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. -
Synonyms
SPACA1;sperm acrosome associated 1;sperm acrosome membrane-associated protein 1;SAMP32;sperm acrosomal membrane-associated protein 32;MGC32952
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Involved Pathway
SPACA1 involved in several pathways and played different roles in them. We selected most pathways SPACA1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPACA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
SPACA1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SPACA1 itself. We selected most functions SPACA1 had, and list some proteins which have the same functions with SPACA1. You can find most of the proteins on our site.
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Interacting Protein
SPACA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPACA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPACA1.
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References
- Streichemberger, E; Perrin, J; et al. Case report of apoptosis in testis of four AZFc-deleted patients: increased DNA fragmentation during meiosis, but decreased apoptotic markers in post-meiotic germ cells. HUMAN REPRODUCTION 27:1939-1945(2012).
- Jones, R; James, PS; et al. The equatorial subsegment in mammalian spermatozoa is enriched in tyrosine phosphorylated proteins. BIOLOGY OF REPRODUCTION 79:421-431(2008).
