SPA17
-
Official Full Name
sperm autoantigenic protein 17 -
Overview
This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22. -
Synonyms
SPA17;sperm autoantigenic protein 17;sperm surface protein Sp17;cancer/testis antigen 22;CT22;SP17;sperm protein 17;SP17-1
Recombinant Proteins
- Human
- Mouse
- Rat
- Rhesus macaque
- Zebrafish
- Cynomolgus
- E.coli
- N-His
- Saccharomyces cerevisiae
- Mammalian Cell
- HEK293
- GST
- His&T7
- Non
- His
- His&Fc&Avi
Involved Pathway
SPA17 involved in several pathways and played different roles in them. We selected most pathways SPA17 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPA17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SPA17 has several biochemical functions, for example, calmodulin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPA17 itself. We selected most functions SPA17 had, and list some proteins which have the same functions with SPA17. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CYS1,EMP3,ATP2A1,CDKL3,JRK,SMARCC1,COMMD5,GRB7,GFAP,HLA-DRB4 |
| calmodulin binding | ENKUR,GRIN1,NOS2,CNN1A,TRPV4,STRN4,PLCB1,MKNK2,CAMK2D1,ARPP21 |
Interacting Protein
SPA17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPA17 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPA17.
ROPN1;AKAP7;MYL6B
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