SP3

  • Official Full Name

    Sp3 transcription factor

  • Overview

    The sequence-specific transcription factor Sp3 binds GC and GT box sequences in the promoters of a variety of genes. The Sp3 transcription factor contains three zinc finger domains that determine sequence specificity of DNA binding. This transcription fac

  • Synonyms

    SP3;Sp3 transcription factor;transcription factor Sp3;SPR 2;specificity protein 3;GC-binding transcription factor Sp3;SPR2;DKFZp686O1631

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • SL2
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Mamanlian cells
  • HEK293T
  • In Vitro Cell Free System
  • His
  • Flag
  • Myc&DDK
  • Non
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SP3-3509H Recombinant Human SP3 protein, His-tagged E.coli Human His 412-590 aa
SP3-2094H Active Recombinant Human Sp3 Transcription Factor, FLAG-tagged SL2 Human Flag
SP3-104H Recombinant Human SP3, MYC/DDK-tagged HEK293 Human Myc&DDK
SP3-15794M Recombinant Mouse SP3 Protein Mammalian Cell Mouse His
SP3-31436TH Recombinant Human SP3 Wheat Germ Human Non 100 amino acids
SP3-6171C Recombinant Chicken SP3 Mammalian Cell Chicken His
SP3-903H Recombinant Human SP3 protein, GST-tagged Wheat Germ Human GST 1-781 a.a.
SP3-301162H Recombinant Human SP3 protein, GST-tagged E.coli Human GST Ile412-Gln590
SP3-4733HFL Recombinant Full Length Human SP3, Flag-tagged Mamanlian cells Human Flag Full L.
SP3-5127H Recombinant Human SP3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Sp3-6061M Recombinant Mouse Sp3 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
SP3-647HF Recombinant Full Length Human SP3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 781 amino acids
SP3-8597M Recombinant Mouse SP3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
SP3-8597M-B Recombinant Mouse SP3 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SP3 involved in several pathways and played different roles in them. We selected most pathways SP3 participated on our site, such as Regulation of Telomerase,SIDS Susceptibility Pathways,Selenium Metabolism and Selenoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of Telomerase DKC1,TNKS,MXD1,PINX1,NR2F2,CMTM2A
    Selenium Metabolism and Selenoproteins TXNRD2,CREM,DIO2,FBXO17,SELK,SELT,TXNRD3IT1,TRNAU1AP,SELENBP1,MSRB1
    SIDS Susceptibility Pathways CDCA7L,TSPYL1,SST,ASCL1,POU3F2,RUNX3,MBD1,TAC1,MAP2,MAZ

    Protein Function

    SP3 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP3 itself. We selected most functions SP3 had, and list some proteins which have the same functions with SP3. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding CA14,ZNF264,GALNT13,ZFP474,LNX2B,CLCNKB,ANTXR2B,CYP19A1B,KDM7AB,ZSWIM4
    RNA polymerase II transcription factor activity, sequence-specific DNA binding FOXC1A,ELF2,MEF2C,PLAGL2,FLI1A,FOXJ1,PLAG1,FOXG1D,ELF2A,NPAS4
    RNA polymerase II regulatory region sequence-specific DNA binding ELF5,LEF1,POGZA,NR1I3,PRDM12B,CREB3,PAX9,SATB1,ZFP551,BARX1
    core promoter proximal region sequence-specific DNA binding CREBBP,CXXC1,DMRT1,DMRT3A,DMRTC2,SMAD4,ZFP516,MIXL1,SP3A,GATA3
    chromatin binding HMGN5,ZKSCAN3,ANKRD17,JUB,YBX1,LDB1,NFATC2,POLD1,GLI3,TAL1
    RNA polymerase II core promoter sequence-specific DNA binding WBP2,GATA1,RREB1,FOS,RUNX2,TP53,EP300,SMAD5,TAL1,TCF7L2
    protein binding TRDN,EP400,PARP4,SPHK2,WWP1,RFPL4,ATP1A2,CALCOCO1,PAQR5,FANCA
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding HELT,MLXIPL,JDP2,NFATC2,BTG2,SKIL,TFAP2A,HMGA2,PRDM1,DLX4

    Interacting Protein

    SP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP3.

    ESR1;GABPA;gc_box_foxp3_promoter_probe;prkra_human_gene;GCH1;HTT;STK19;q5nig6_fratt;dnaC_26;yfkA;mdm2_human_probe;bmf_human_gene

    Resources

    References

    • Mizukami, M; Tokunaga, H; et al. Highly efficient production of VHH antibody fragments in Brevibacillus choshinensis expression system. PROTEIN EXPRESSION AND PURIFICATION 105:23-32(2015).
    • Yang, Y; Deng, Y; et al. The Amino Acids 736-761 of the MERS-CoV Spike Protein Induce Neutralizing Antibodies: Implications for the Development of Vaccines and Antiviral Agents. VIRAL IMMUNOLOGY 27:543-550(2014).

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