SOX12
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Official Full Name
SRY (sex determining region Y)-box 12 -
Overview
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. -
Synonyms
SOX12;SRY (sex determining region Y)-box 12;SOX22, SRY (sex determining region Y) box 22;transcription factor SOX-12;Homo sapiens SRY (sex determining region Y) box 12;Protein SOX-22;SOX 12;SOX 12 protein;SOX 22;SOX 22 protein;SOX12 protein;SOX12_HUMAN;SOX22 protein;SRY (sex determining region Y) box 12;SRY (sex determining region Y) box 22;SRY box 12;SRY box 22;SRY related HMG box gene 22;SOX-22 protein;OTTHUMP00000029906;SRY-related HMG-box gene 22;SRY (sex determining region Y)-box 22;SOX22
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SOX12-15774M | Recombinant Mouse SOX12 Protein | Mammalian Cell | Mouse | His |
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| SOX12-3355Z | Recombinant Zebrafish SOX12 | Mammalian Cell | Zebrafish | His |
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| SOX12-1671HCL | Recombinant Human SOX12 cell lysate | Human | Non |
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| SOX12-8585M | Recombinant Mouse SOX12 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SOX12-8585M-B | Recombinant Mouse SOX12 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SOX12 involved in several pathways and played different roles in them. We selected most pathways SOX12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SOX12 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription coactivator activity,transcription regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX12 itself. We selected most functions SOX12 had, and list some proteins which have the same functions with SOX12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | BARHL2,GATA2,GABPA,GATA3,GRHL1,TLX1,POU4F3,MAFB,ELK3,NFKB2 |
| RNA polymerase II transcription coactivator activity | HYAL2,NEUROD1,MKL1,MKL1B,MED12,RERE,SOX11,NCOA1,ISL1,CREBBP |
| DNA binding | RFX8,NHEJ1,MKXB,FOXP1B,EGR4,ZNF2,TFPT,ZFP13,SSBP3B,C19orf40 |
| transcription regulatory region sequence-specific DNA binding | FOXN1,POU2F1,NR5A5,BACH1B,TFAP2A,SOX2,EGR1,SUV39H1,NKX3,NFE2L2 |
Interacting Protein
SOX12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX12 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX12.
SRM;POLD2;SMAD4
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