SORBS2
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Official Full Name
sorbin and SH3 domain containing 2 -
Overview
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
SORBS2;sorbin and SH3 domain containing 2;sorbin and SH3 domain-containing protein 2;Arg/Abl interacting protein;ARGBP2;KIAA0777;Arg/Abl interacting protein 2;Arg binding protein 2;Arg/Abl-interacting protein 2;PRO0618
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SORBS2-5670R | Recombinant Rat SORBS2 Protein | Mammalian Cell | Rat | His |
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| SORBS2-1570HCL | Recombinant Human SORBS2 293 Cell Lysate | HEK293 | Human | Non |
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| SORBS2-1571HCL | Recombinant Human SORBS2 293 Cell Lysate | HEK293 | Human | Non |
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| SORBS2-5329R | Recombinant Rat SORBS2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SORBS2-5329R-B | Recombinant Rat SORBS2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Sorbs2-6045M | Recombinant Mouse Sorbs2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
SORBS2 involved in several pathways and played different roles in them. We selected most pathways SORBS2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SORBS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SORBS2 has several biochemical functions, for example, cytoskeletal adaptor activity,metal ion binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SORBS2 itself. We selected most functions SORBS2 had, and list some proteins which have the same functions with SORBS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FBXW11,GLB1,GRIP1,KIF5A,SEC31A,ARNTL,ZBTB25,COX5A,TMPRSS15,SETD7 |
| protein domain specific binding | HOMER2,HIST1H4K,AKAP5,RCC2,ATN1,RAB27B,FAF1,TACC1,RAB27A,NCK1 |
| metal ion binding | BMPR1A,ZC3H7A,ARMC1L,ZNF581,IRF2BP1,CYP19A1B,NRAP,BTR18,UBR1,TRIM50 |
| cytoskeletal adaptor activity | BAIAP2,NCK2,BAIAP2L2B,ABI2,ANK1,BAIAP2L2,SDCBP,BAIAP2A,COX4I2,BAIAP2L1 |
| structural constituent of muscle | JPH1,PDLIM3,MYOT,PLEC,TTN,MYL3,SMTN,TPM2,MYBPC3,NEBL |
| poly(A) RNA binding | NCL,MTIF2,CDC42EP4,EBNA1BP2,CCDC55,SLIRP,HNRNPU,SNRNP70,HNRNPD,CDC40 |
| structural constituent of cytoskeleton | LOR,NDC80,SPTBN2,ADD3,DES,TUBA3D,AGRN,CTNNA2,GFAP,PLS1 |
Interacting Protein
SORBS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SORBS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SORBS2.
AKT1;PAK1
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References
- Lamberti, A; Sanges, C; et al. Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. BIOCHIMIE 93:1738-1746(2011).
