SOCS4
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Official Full Name
suppressor of cytokine signaling 4 -
Overview
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. -
Synonyms
SOCS4;suppressor of cytokine signaling 4;SOCS7, suppressor of cytokine signaling 7;SOCS-4;SOCS-7;suppressor of cytokine signaling 7;SH2 domain containing SOCS box protein;SOCS7;DKFZp686J1568
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SOCS4-344H | Recombinant Human SOCS4 Protein, His-tagged | E.coli | Human | His |
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| SOCS4-345H | Recombinant Human SOCS4 Protein, His-tagged | E.coli | Human | His |
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| SOCS4-4238C | Recombinant Chicken SOCS4 | Mammalian Cells | Chicken | His |
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| SOCS4-4403R | Recombinant Rhesus monkey SOCS4 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| SOCS4-6262Z | Recombinant Zebrafish SOCS4 | Mammalian Cells | Zebrafish | His |
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| SOCS4-1666HCL | Recombinant Human SOCS4 cell lysate | Human | Non |
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| SOCS4-4219R | Recombinant Rhesus Macaque SOCS4 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SOCS4-4219R-B | Recombinant Rhesus Macaque SOCS4 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
SOCS4 involved in several pathways and played different roles in them. We selected most pathways SOCS4 participated on our site, such as Insulin signaling pathway,Jak-STAT signaling pathway,Kit Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOCS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Type II diabetes mellitus | PIK3R5,TNF,MAPK8,SLC2A4,PIK3CB,PRKCD,MAPK1,HK1,IRS2,INS1 |
| Prolactin signaling pathway | STAT3,MAPK9,ESR2,TNFSF11,PPIB,SOCS2,PIK3CA,TNFRSF11A,SOCS3,PIK3CG |
| Kit Receptor Signaling Pathway | GRAPA,SPRED2B,GRAP,DOK1,STAP1,GRB10,PTPRUB,GRB7,PTPRU,DOK1B |
| Insulin signaling pathway | AKT2L,PRKACBA,PHKA1,CBL,MAPK8,MAPK3,PRKAG1,G6PC2,FLOT1A,SOCS3 |
| Jak-STAT signaling pathway | IL4R,NT5C3,IL2RGB,IL11RA,IL22,GHRA,STAT2,IFNA8,PIK3CB,IL-15RA |
Protein Function
SOCS4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOCS4 itself. We selected most functions SOCS4 had, and list some proteins which have the same functions with SOCS4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RBMY1B,KLF4,IWS1,TTYH2,ITM2B,ZNF460,SMURF1,TIMM21,FGF21,NFKBIZ |
Interacting Protein
SOCS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOCS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOCS4.
GRB2;PIK3R3;RBP7;PINK1;FRS3;ppapdc2;LECT1;TNK2
SOCS4 Related Signal Pathway
Resources
Related Services
Related Products
References
- Rutz, S; Kayagaki, N; et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. NATURE 518:-(2015).
- Guo, H; Wang, Y; et al. Platelet Factor 4 Limits Th17 Differentiation and Ischaemia-Reperfusion Injury After Liver Transplantation in Mice. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:129-134(2015).
