SNX3
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Official Full Name
sorting nexin 3 -
Overview
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. -
Synonyms
SNX3;sorting nexin 3;sorting nexin-3;Grd19;MCOPS8;MGC151262;MGC151266;MGC17570;OTTHUMP00000016941;OTTHUMP00000046475;OTTHUMP00000046476;Protein SDP3;SDP3;SNX3_HUMAN;SNX3A;Sorting nexin 3A
Recombinant Proteins
- Chicken
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
SNX3 involved in several pathways and played different roles in them. We selected most pathways SNX3 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | PDCD6IP,STAMBPB,ERBB4A,RAB11BB,CCDC53,CXCR2,EHD4,IL2RGB,SNX1,IL2RG |
Protein Function
SNX3 has several biochemical functions, for example, phosphatidylinositol-3,5-bisphosphate binding,phosphatidylinositol-3-phosphate binding,phosphatidylinositol-4-phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX3 itself. We selected most functions SNX3 had, and list some proteins which have the same functions with SNX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KDRL,AUNIP,SDC1,PIAS3,YWHAB,SNX27,GP5,FYTTD1,ZG16,CEP350 |
| phosphatidylinositol-3-phosphate binding | SNX20,SNX27,NCF4,PARD3,WIPI2,D6WSU116E,WDR45,SNX13,SESTD1,TECPR1 |
| phosphatidylinositol-4-phosphate binding | OSBP,SNX24,ARFIP1,OSBPL8,OSBPL5,PLEKHA8,LANCL2,D6WSU116E,MBL1,GOLPH3 |
| phosphatidylinositol-3,5-bisphosphate binding | KIF16B,COMMD1,SNX14,WDR45B,PHLDA3,MAPKAP1,JPH2,WDR45L,GBF1,SH3PXD2B |
| protein phosphatase binding | AP3B1,NEK2,MAP2K7,KAT2A,HSF4,STAT3,FGF19,DLG3,PARD3,GRB2 |
| phosphatidylinositol-5-phosphate binding | RS1,PLEKHF1,JPH2,PHLDA3,D6WSU116E,SESTD1,LANCL2,SNX24,WIPI2,FAM21C |
Interacting Protein
SNX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX3.
ARL6IP1;ABL1;FYN;EPB41;SRC;NCK1;MCC;HLA-B;VHL;CRK;GRB2;IKBKE;ATG5;STX11;PDE4DIP;pi3p
Resources
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References
- Xu, Y; Hortsman, H; et al. SNX3 regulates endosomal function through its PX-domain-mediated interaction with Ptdlns(3)P. NATURE CELL BIOLOGY 3:658-666(2001).
- Tai, GH; Lu, L; et al. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. MOLECULAR BIOLOGY OF THE CELL 15:4011-4022(2004).
