SNX14
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Official Full Name
sorting nexin 14 -
Overview
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Two transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
SNX14;sorting nexin 14;sorting nexin-14;RGS PX2;MGC13217;RGS-PX2;RP11-321N4.2;SNX14_HUMAN;OTTHUMP00000016812;OTTHUMP00000016813;OTTHUMP00000220929;OTTHUMP00000220930;OTTHUMP00000220931;OTTHUMP00000220932
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SNX14-2856H | Recombinant Human SNX14, GST-tagged | E.coli | Human | GST | 596-893aa | |
| SNX14-3350C | Recombinant Chicken SNX14 | Mammalian Cell | Chicken | His |
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| SNX14-3933Z | Recombinant Zebrafish SNX14 | Mammalian Cell | Zebrafish | His |
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| SNX14-4390R | Recombinant Rhesus monkey SNX14 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SNX14-1659HCL | Recombinant Human SNX14 cell lysate | Human | Non |
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| SNX14-4206R | Recombinant Rhesus Macaque SNX14 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SNX14-4206R-B | Recombinant Rhesus Macaque SNX14 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
SNX14 involved in several pathways and played different roles in them. We selected most pathways SNX14 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SNX14 has several biochemical functions, for example, phosphatidylinositol-3,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX14 itself. We selected most functions SNX14 had, and list some proteins which have the same functions with SNX14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol-3,5-bisphosphate binding | JPH2,RS1,KIF16B,D6WSU116E,SNX3,WDR45L,CLVS2,WDR45,WIPI1,FAM21C |
Interacting Protein
SNX14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX14 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX14.
q99ib8-pro_0000045601;pi3p
Resources
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References
- Huang, HS; Yoon, BJ; et al. Snx14 Regulates Neuronal Excitability, Promotes Synaptic Transmission, and Is Imprinted in the Brain of Mice. PLOS ONE 9:-(2014).
- Thomas, AC; Williams, H; et al. Mutations in SNX14 Cause a Distinctive Autosomal-Recessive Cerebellar Ataxia and Intellectual Disability Syndrome. AMERICAN JOURNAL OF HUMAN GENETICS 95:611-621(2014).
