SNRPA
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Official Full Name
small nuclear ribonucleoprotein polypeptide A -
Overview
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. -
Synonyms
SNRPA;small nuclear ribonucleoprotein polypeptide A;U1 small nuclear ribonucleoprotein A;Mud1;U1 A;U1A;U1 snRNP A;U1 snRNP-specific protein A;U1 small nuclear RNP-specific A;U1-A
Recombinant Proteins
- Human
- Mouse
- HEK293
- E.coli
- E. coli
- Insect cells
- His&Fc&Avi
- N-His&C-Myc
- His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SNRPA-2060H | Recombinant Human SNRPA Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| SNRPA-2060H-B | Recombinant Human SNRPA Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| SNRPA-2097H | Recombinant Human SNRPA protein, His&Myc-tagged | E.coli | Human | N-His&C-Myc | 2-282aa |
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| SNRPA-2607H | Recombinant Human SNRPA protein(111-190 aa), C-His-tagged | E.coli | Human | His | 111-190 aa |
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| SNRPA-2778H | Recombinant Human SNRPA protein, His-tagged | E. coli | Human | His | 297aa(including fusion tag) |
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| Snrpa-643M | Recombinant Mouse Snrpa protein(1-287aa), His&Myc-tagged | E.coli | Mouse | N-His&C-Myc | 1-287aa |
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| SNRPA-6685H | Recombinant Human SNRPA protein, His-tagged | Insect cells | Human | His | 2-282aa |
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Involved Pathway
SNRPA involved in several pathways and played different roles in them. We selected most pathways SNRPA participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNRPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | THOC2,SNRNP70,SARNP,SF3B14,TCERG1A,TRA2B,HSPA1B,PRPF4,LSM2,DDX46 |
Protein Function
SNRPA has several biochemical functions, for example, RNA binding,U1 snRNA binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNRPA itself. We selected most functions SNRPA had, and list some proteins which have the same functions with SNRPA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF10,KIAA1217,NUP37,BTG1,IL28RA,TRIM39,CD82,TSC1,SORL1,STAT4 |
| snRNA stem-loop binding | SNRPB2 |
| RNA binding | IMPDH1,TRIM32,EIF3BA,PPARGC1A,CELF2,RNASEL2,RNASET2,CPSF3,RBMX,DAZAP1 |
| poly(A) RNA binding | C3orf26,PTBP2,EIF1,FKBP3,SYNCRIP,MEX3B,NAT10,FTSJ3,RPS8,MAP4 |
| nucleotide binding | NADKD1,PRKCDA,RAB1BB,LRGUK,RPS6KAL,HNRNPDL,REV3L,NIM1,ARL4CB,SF3B6 |
| U1 snRNA binding | SNRNP70,PRPF8,ISG20 |
Interacting Protein
SNRPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNRPA here. Most of them are supplied by our site. Hope this information will be useful for your research of SNRPA.
PTBP1;U2AF2;SNRPA1;SFPQ;TRIM27
Resources
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References
- Wood, JD; Liu, SM; et al. Anti-Enteric Neuronal Antibodies and the Irritable Bowel Syndrome. JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY 18:78-85(2012).
- Kaneko, Y; Suwa, A; et al. Clinical associations with autoantibody reactivities to individual components of U1 small nuclear ribonucleoprotein. LUPUS 19:307-312(2010).
