SMYD3
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Official Full Name
SET and MYND domain containing 3 -
Synonyms
SMYD3;SET and MYND domain containing 3;zinc finger, MYND domain containing 1, ZMYND1, ZNFN3A1;SET and MYND domain-containing protein 3;KMT3E;bA74P14.1 (novel protein);zinc finger, MYND domain containing 1;zinc finger MYND domain-containing protein 1;zinc finger protein, subfamily 3A (MYND domain containing), 1;ZMYND1;ZNFN3A1;bA74P14.1;FLJ21080;MGC104324
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Insect Cells
- Mammalian Cell
- Sf9 Insect Cell
- E.coli
- HEK293
- Human Cell
- Insect Cell
- HEK293T
- Yeast
- GST
- His
- His&Flag
- Non
- His&SUMO
- Myc&DDK
- His&Fc&Avi
- N-Flag&C-His-Myc
- N-His&C-Myc
Involved Pathway
SMYD3 involved in several pathways and played different roles in them. We selected most pathways SMYD3 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,PKMTs methylate histone lysines, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMYD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PKMTs methylate histone lysines | SUZ12,SETD3,ATF7IP,DPY30,RBBP5,SUZ12A,SMYD2A,SUZ12B,AEBP2,PRDM16 |
| Chromatin modifying enzymes | CSRP2BP,KAT5,ARID2,ING3,PRMT7,MBD3B,MTA1,KAT7B,C20orf20,GATAD2B |
| Chromatin organization | KDM4C,PHF20B,SMARCD3,MTA1,SMARCD1,ASH2L,KDM3B,EHMT2,MSL2B,RUVBL2 |
Protein Function
SMYD3 has several biochemical functions, for example, RNA polymerase II core binding,RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMYD3 itself. We selected most functions SMYD3 had, and list some proteins which have the same functions with SMYD3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone-lysine N-methyltransferase activity | MLL1,AAAS,MLL5,WBP7,SETD1B,SETDB1B,WHSC1L1,EHMT1B,PRDM6,EHMT2 |
| RNA polymerase II core binding | ZNF326,SMYD2,SMYD2A,AGO2,ZFP326,PCF11,GTF2E1,PAF1,C14orf166,CTR9 |
| RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding | VAX1,NCOA2,VAX2,ZNF350,HSF2,ZC3H8,HSF1 |
| RNA polymerase II core promoter sequence-specific DNA binding | ZFP335,TCF7L2,MITF,H3F3A,TAL1,EP300,SOX3,GATA3,GBX2,NR4A2 |
| metal ion binding | KLF11,ZNF32,PFKL,MUL1B,ZCCHC18,TGM1,GNAT1,Gh,G2E3,RUFY2 |
Interacting Protein
SMYD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMYD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMYD3.
DDOST;MEST;FAR1;NDUFAB1;NFYB;PBX2;CAMK2B;ZNF57;H3F3C;VANGL1;TRIT1;CYP39A1;q9wmx2-pro_0000037551;polg_hcvh;CDC37
Resources
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References
- Spellmon, N; Holcomb, J; et al. Structure and Function of SET and MYND Domain-Containing Proteins. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16:1406-1428(2015).
- Xu, GL; Liu, GL; et al. The Histone Methyltransferase Smyd2 Is a Negative Regulator of Macrophage Activation by Suppressing Interleukin 6 (IL-6) and Tumor Necrosis Factor alpha (TNF-alpha) Production. JOURNAL OF BIOLOGICAL CHEMISTRY 290:5414-5423(2015).
