SMPD4
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Official Full Name
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -
Overview
Sphingomyelinases (EC 3.1.4.12), such as SMPD4, catalyze the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (Krut et al., 2006 (PubMed 16517606)). -
Synonyms
SMPD4;sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3);sphingomyelin phosphodiesterase 4;FLJ20297;FLJ20756;KIAA1418;NET13;nSMase 3;NSMASE3;Neutral sphingomyelinase 3;Neutral sphingomyelinase III;NSMA3_HUMAN;nSMase-3;OTTHUMP00000162391;OTTHUMP00000190862;SKNY protein;Sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase 3)
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- zebrafish
- E.coli
- Mammalian Cell
- E.coli expression system
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SMPD4-2821H | Recombinant Human SMPD4, His-tagged | E.coli | Human | His | 1-350aa | |
| SMPD4-12535Z | Recombinant Zebrafish SMPD4 | Mammalian Cell | Zebrafish | His |
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| SMPD4-15642M | Recombinant Mouse SMPD4 Protein | Mammalian Cell | Mouse | His |
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| RFL7148DF | Recombinant Full Length Danio Rerio Sphingomyelin Phosphodiesterase 4(Smpd4) Protein, His-Tagged | E.coli expression system | zebrafish | His | Full L. Full Length (1-791) |
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| Smpd4-2087M | Recombinant Mouse Smpd4 Protein, His-tagged | E.coli | Mouse | His | Met1-Phe185 |
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| SMPD4-2709H | Recombinant Human SMPD4 Protein, His-tagged | E.coli | Human | His | Ala10-His148 |
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| SMPD4-8496M | Recombinant Mouse SMPD4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SMPD4-8496M-B | Recombinant Mouse SMPD4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SMPD4 involved in several pathways and played different roles in them. We selected most pathways SMPD4 participated on our site, such as Sphingolipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMPD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ALG9,B3GALNT1,COMTA,OGDH,AZIN2,UGT1AB,HSD17B12,ATP6V1C1,GBE1,MUT |
| Sphingolipid metabolism | DEGS1,ENPP7,R05D11.9,SMPD5,GBA2,LASS2,NEU3.4,SGPP1,NEU3.1,ASAH1A |
Protein Function
SMPD4 has several biochemical functions, for example, metal ion binding,sphingomyelin phosphodiesterase D activity,sphingomyelin phosphodiesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMPD4 itself. We selected most functions SMPD4 had, and list some proteins which have the same functions with SMPD4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sphingomyelin phosphodiesterase D activity | R05D11.9 |
| sphingomyelin phosphodiesterase activity | SMPD3,SMPD2,SMPD1,ENPP7,SMPD2A,SMPDL3B,SMPD5,SMPDL3A |
| metal ion binding | PVALB6,HAND2,PDE4B,SMYD2,SOBP,ADSSL,SP8A,HPX,RASA3,PRKD3 |
Interacting Protein
SMPD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMPD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMPD4.
BRF2;EXOSC4;E2F3
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