SMOC2
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Official Full Name
SPARC related modular calcium binding 2 -
Overview
This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. -
Synonyms
SMOC2;SPARC related modular calcium binding 2;SPARC-related modular calcium-binding protein 2;SMAP2;SMAP-2;SMOC-2;smooth muscle associated protein 2;smooth muscle-associated protein 2;secreted modular calcium-binding protein 2;thyroglobulin type-
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Smoc2-311M |
Active Recombinant Mouse Smoc2, His-tagged
|
Mammalian cells | Mouse | His | 30-447 a.a. |
|
| SMOC2-332H |
Active Recombinant Human SMOC2, His-tagged
|
CHO | Human | His | 22-446 a.a. |
|
| SMOC2-15633M | Recombinant Mouse SMOC2 Protein | Mammalian Cell | Mouse | His |
|
|
| SMOC2-1657HCL | Recombinant Human SMOC2 293 Cell Lysate | HEK293 | Human | Non |
|
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| Smoc2-8489M | Recombinant Mouse Smoc2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
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| Smoc2-8489M-B | Recombinant Mouse Smoc2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
SMOC2 involved in several pathways and played different roles in them. We selected most pathways SMOC2 participated on our site, such as Gastric cancer network 1, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMOC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gastric cancer network 1 | MYBL2,ESM1,ECT2,C21orf33,TPX2,RNF216,LIN9,ACTL6A,GATS,S100P |
Protein Function
SMOC2 has several biochemical functions, for example, calcium ion binding,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMOC2 itself. We selected most functions SMOC2 had, and list some proteins which have the same functions with SMOC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparin binding | NAV2,OGN,FGFR2,PCSK6,NRP2,CXCL10,FGF4,MMP7,PCOLCE,HSD17B12 |
| calcium ion binding | PCDH2AB9,EFEMP2A,SCGN,NDUFAB1,DGKB,CDH7,CALML5,SPTAN1,FBN2,LRP2 |
Interacting Protein
SMOC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMOC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMOC2.
Resources
Research Area
Osteoclast MarkersCalcium-binding Proteins and Related Molecules
Osteoblast and Osteoclast Markers
Extracellular Matrix Molecules
Related Services
Related Products
References
- Choi, YA; Kim, DS; et al. SMOC1-induced Osteoblast Differentiation Involves Enhanced Proliferation of Human Bone Marrow Mesenchymal Stem Cells. TISSUE ENGINEERING AND REGENERATIVE MEDICINE 11:304-316(2014).
- Smalling, RL; Delker, DA; et al. Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 305:G364-G374(2013).
