SMG1
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Official Full Name
SMG1 phosphatidylinositol 3-kinase-related kinase -
Overview
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013] -
Synonyms
SMG1;SMG1 phosphatidylinositol 3-kinase-related kinase;ATX;LIP;61E3.4;serine/threonine-protein kinase SMG1;lambda-interacting protein;PI-3-kinase-related kinase SMG-1;lambda/iota protein kinase C-interacting protein;smg-1 homolog, phosphatidylinositol 3-kinase-related kinase
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SMG1-15622M | Recombinant Mouse SMG1 Protein | Mammalian Cell | Mouse | His |
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| SMG1-4986Z | Recombinant Zebrafish SMG1 | Mammalian Cell | Zebrafish | His |
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| SMG1-13H | Recombinant Human SMG1 Protein, 2922-3031, N-GST tagged | Wheat Germ (in vitro) | Human | GST | 2922-3031 |
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| SMG1-8478M | Recombinant Mouse SMG1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SMG1-8478M-B | Recombinant Mouse SMG1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SMG1 involved in several pathways and played different roles in them. We selected most pathways SMG1 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA surveillance pathway | PPP2R5EA,CSTF2T,WDR33,PPP1CA,SSU72,CPSF2,GSPT2,PPP2R5D,DDX39B,PPP2R1A |
Protein Function
SMG1 has several biochemical functions, for example, ATP binding,kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMG1 itself. We selected most functions SMG1 had, and list some proteins which have the same functions with SMG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | GRSF1,FUS,ATP1A1A.4,UBE2L3A,PABPC3,ARF3B,DOM3Z,CKMT2A,MAPK8B,KIF27 |
| metal ion binding | ZNF718,AGO2,LMO7A,CNBPA,NDUFS7,GFI1B,CACNA2D4,PRKCBP1L,GDPD4,ZFP553 |
| protein serine/threonine kinase activity | SNRKB,ROCK2B,MAPK6,PRKCBA,HUNK,RIOK1,CDK11A,MAP4K6,BCKDK,MAPK1 |
| kinase activity | BCR,CAMK1DA,ACVR1BA,UCK2A,PRKACAB,PKN2,GM7168,PIK3CA,RPS6KA3A,KDRL |
| transferase activity | STK30,MARCKSB,MAPK12B,PRDM9,SULT5A1,CDK5R1A,SULT1ST1,ERBB3A,UHMK1,C1GALT1B |
| phosphotransferase activity, alcohol group as acceptor | FAM20B,POMK,SGK196,PI4KAA,GKUP,FGGY,PI4KAB,G6PC,PI4KAP2,ADKA |
| protein dimerization activity | SLC4A11,FBXW11A,MXD4,MYCH,PDCD6,SIM1A,MYC,HNF1BA,POU2F3,POLR2J3 |
| ATP binding | YTHDC2,FGFR1A,LIG3,PSTK,GRK7B,MAP3K13,ABCC10,MAPK9,MAP2K1,ATP11A |
| poly(A) RNA binding | PYDC3,RPP30,GPATCH4,SF3A3,PEBP1,MAP4,SFPQ,RPS17L,ISY1,NVL |
Interacting Protein
SMG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMG1.
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References
- Cho, H; Han, S; et al. SMG1 regulates adipogenesis via targeting of staufenl-mediated mRNA decay. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1829:1276-1287(2013).
- Henderson-Smith, A; Chow, D; et al. SMG1 Identified as a Regulator of Parkinson's Disease-Associated alpha-Synuclein through siRNA Screening. PLOS ONE 8:-(2013).
