SLCO1B3
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Official Full Name
solute carrier organic anion transporter family, member 1B3 -
Overview
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a;transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a;critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type;hyperbilirubinemia. -
Synonyms
SLCO1B3;solute carrier organic anion transporter family, member 1B3;SLC21A8, solute carrier family 21 (organic anion transporter), member 8;solute carrier organic anion transporter family member 1B3;OATP1B3;OATP8;organic anion transporter 8;organi
Recombinant Proteins
- Rhesus macaque
- Rat
- Cynomolgus
- Human
- Mammalian Cell
- HEK293
- His
- Non
- His&Fc&Avi
Involved Pathway
SLCO1B3 involved in several pathways and played different roles in them. We selected most pathways SLCO1B3 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLCO1B3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile secretion | Car2,PRKACG,OSTA,SLCO1B1,NCEH1,LDLR,SLCO1A5,SCTR,Abcb1b,FAM84B |
Protein Function
SLCO1B3 has several biochemical functions, for example, bile acid transmembrane transporter activity,organic anion transmembrane transporter activity,sodium-independent organic anion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLCO1B3 itself. We selected most functions SLCO1B3 had, and list some proteins which have the same functions with SLCO1B3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sodium-independent organic anion transmembrane transporter activity | SLCO4C1,SLCO1A4,SLCO1F1,SLC22A24,SLCO1A2,SLC22A12,SLCO1B1,SLC22A7,SLC22A6,SLCO2B1 |
| bile acid transmembrane transporter activity | SLCO1D1,SLCO1F3,SLCO1B1,SLCO1A2,SLCO2B1,SLCO1A4,SLCO1B2,SLCO1F1,SLCO1F4,SLCO1C1 |
| organic anion transmembrane transporter activity | SLC22A7B.1,SLC22A20,SLC17A3,ABCC5,SLC22A7A,SLC22A6,SLCO1A2,SLC22A23,ABCC2,SLC22A31 |
Interacting Protein
SLCO1B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLCO1B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLCO1B3.
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