SLCO1B1

  • Official Full Name

    Solute Carrier Organic Anion Transporter Family, Member 1B1

  • Overview

    This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. Synthetic C-terminus (21 aa) of human organic anion transporter SLC21A6 coupled to KLH.

  • Synonyms

    SLCO1B1;solute carrier organic anion transporter family, member 1B1;LST1;LST-1;OATP2;OATPC;OATP-C;OATP1B1;SLC21A6;solute carrier organic anion transporter family member 1B1;OATP-2;solute carrier family 21 member 6;liver-specific organic anion transporter 1;sodium-independent organic anion-transporting polypeptide 2;solute carrier family 21 (organic anion transporter), member 6;Human Hepatic OATP2 (OATP1B1);Organic Anion Transporter SLC21A6;MGC133282;OTTHUMP00000239999

Recombinant Proteins

  • Human
  • Cynomolgus
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • Insect Cell
  • E.coli
  • GST
  • His
  • Non
  • His&Flag&MBP
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SLCO1B1-27769TH Recombinant Human SLCO1B1 Protein, GST-tagged Wheat Germ Human GST 481 a.a. - 570 a.a.
SLCO1B1-940C Recombinant Cynomolgus SLCO1B1 Protein, His-tagged Mammalian Cell Cynomolgus His
SLCO1B1-1689HCL Recombinant Human SLCO1B1 293 Cell Lysate HEK293 Human Non
SLCO1B1-0669H Recombinant Human SLCO1B1 Protein (D2-C691), 8×His-MBP, Flag tagged Insect Cell Human His&Flag&MBP D2-C691
SLCO1B1-5562H Recombinant Human SLCO1B1 Protein (Phe426-Phe537), N-His tagged E.coli Human His Phe426-Phe537
SLCO1B1-683C Recombinant Cynomolgus Monkey SLCO1B1 Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus His&Fc&Avi
SLCO1B1-683C-B Recombinant Cynomolgus Monkey SLCO1B1 Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus

    Involved Pathway

    SLCO1B1 involved in several pathways and played different roles in them. We selected most pathways SLCO1B1 participated on our site, such as Bile acid and bile salt metabolism,Bile secretion,Drug Induction of Bile Acid Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLCO1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bile acid and bile salt metabolism CYP7A1,NCOA2,CYP27A1,BRSK2,SLC27A2,CYP8B2,Alb,AKR1C4,SLC27A5,AKR1C2
    Drug Induction of Bile Acid Pathway SLC51B,NR1I3,CYP7A1,NR1I2,ABCC2
    SLC-mediated transmembrane transport SLC39A7,SLC6A1B,PDZD11,SLC3A2A,SLC2A10,SLC28A2,SLC2A15A,RHCGA,RHCGB,SLC6A11
    Metabolism of lipids and lipoproteins FABP1B.1,MED7,CLPS,MED9,Alb,MED25,GPAT2,PMVK,SACM1LA,CPNE1
    Bile secretion NR1H4,PRKACB,ADCY3,FXYD2,SLCO1A4,HMGCR,ABCB11,SCARB1,CYP3A4,PRKACA
    Metabolism AKR1B15,NQO1,CYP3C4,VAPB,TPTE,CHST14,TREH,MTP,ACOT11B,ARSK

    Protein Function

    SLCO1B1 has several biochemical functions, for example, bile acid transmembrane transporter activity,sodium-independent organic anion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLCO1B1 itself. We selected most functions SLCO1B1 had, and list some proteins which have the same functions with SLCO1B1. You can find most of the proteins on our site.

    Function Related Protein
    bile acid transmembrane transporter activity SLCO1A4,SLCO1F1,SLCO1B3,SLCO2B1,SLCO1D1,SLCO1A6,SLCO1B2,SLCO1C1,SLCO1F3,SLCO1A2
    sodium-independent organic anion transmembrane transporter activity SLCO1A6,SLC22A7,SLC22A8,SLCO1A5,SLCO1C1,SLCO1A4,SLCO1F4,SLCO3A1,SLCO1F3,SLCO1F2

    Interacting Protein

    SLCO1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLCO1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLCO1B1.

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