SLCO1A2
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Official Full Name
solute carrier organic anion transporter family, member 1A2 -
Overview
This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. -
Synonyms
SLCO1A2;solute carrier organic anion transporter family, member 1A2;SLC21A3, solute carrier family 21 (organic anion transporter), member 3;solute carrier organic anion transporter family member 1A2;OATP;OATP A;OATP1A2;OATP-1;solute carrier famil
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- His
- Non
- His&Flag&MBP
- His&Fc&Avi
Involved Pathway
SLCO1A2 involved in several pathways and played different roles in them. We selected most pathways SLCO1A2 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLCO1A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile secretion | SCARB1,ABCC3,SLC5A1,SLC4A4,PRKACB,ATP1A1,OSTA,ATP1B3,ABCG8,AQP9 |
Protein Function
SLCO1A2 has several biochemical functions, for example, bile acid transmembrane transporter activity,organic anion transmembrane transporter activity,sodium-independent organic anion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLCO1A2 itself. We selected most functions SLCO1A2 had, and list some proteins which have the same functions with SLCO1A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sodium-independent organic anion transmembrane transporter activity | SLCO1B1,SLCO1B3,SLCO1F1,SLCO1A6,SLC22A7,SLCO4A1,SLCO1F4,SLCO1C1,SLC22A24,SLC22A9 |
| bile acid transmembrane transporter activity | SLCO1C1,SLCO1A4,SLCO1B2,SLCO1F3,SLCO2B1,SLCO1F4,SLCO1B3,SLCO1F2,SLCO1F1,AKR1C4 |
| organic anion transmembrane transporter activity | SLCO1B2,SLCO3A1,MFSD10,SLC22A23,ABCC3,SLC22A6,ABCC2,ABCC11,SLCO1A5,SLCO1B3 |
Interacting Protein
SLCO1A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLCO1A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLCO1A2.
rpoB
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