SLC9A1

  • Official Full Name

    solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1

  • Overview

    SLC9A1 (NHE1), a member of the Na+/H+ exchanger family, is a ubiquitous membrane protein that regulates intracellular pH and cell volume. Furthermore, SLC9A1 is known to interact with the actin cytoskeleton. Fibroblasts expressing mutated NHE1 that fails

  • Synonyms

    SLC9A1;solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1;APNH, NHE1, solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) , solute carrier family 9 (sodium/hydrogen ex
Cat.# Product name Source (Host) Species Tag Protein Length Price
SLC9A1-3435C Recombinant Chicken SLC9A1 Mammalian Cell Chicken His
SLC9A1-5584R Recombinant Rat SLC9A1 Protein Mammalian Cell Rat His
SLC9A1-6293Z Recombinant Zebrafish SLC9A1 Mammalian Cell Zebrafish His
SLC9A1-1695HCL Recombinant Human SLC9A1 293 Cell Lysate HEK293 Human Non
SLC9A1-5243R Recombinant Rat SLC9A1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
SLC9A1-5243R-B Recombinant Rat SLC9A1 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    SLC9A1 involved in several pathways and played different roles in them. We selected most pathways SLC9A1 participated on our site, such as cAMP signaling pathway,Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC9A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adrenergic signaling in cardiomyocytes PPP2R5EB,PPP1CAB,ATP2B4,SCN5A,PRKACAA,ATP1A2,PRKACAB,PIK3CG,ATP1A3B,ADRB3B
    Pancreatic secretion ATP2B1,PRSS2,PLA2G12B,CELA2A,ATP1B3,SLC4A4,PLCB1,ATP2A2,CPB2,CELA3A
    Regulation of Actin Cytoskeleton FGF11A,SRC,PIK3R5,ITGB1A,PDGFRA,FGF16,ARPC5LB,CHRM5A,MAP2K1,GIT1
    cAMP signaling pathway CNGA2,GHSR,SOX9,HTR1A,MAPK1,FXYD1,VAV2,HTR1E,PDE3B,PIK3CB
    Cardiac muscle contraction MYL2,CACNG6A,MYL3,CACNB2,TNNC1,CACNA2D1,TMEM8C,COX6A1,ATP2A2,CACNB3A
    Bile secretion SLCO1A5,ABCC3,ADCY8,SLCO1B2,SULT2A1,ABCG8,PRKACB,CYP3A4,ATP1A4,ATP1B4
    Gastric acid secretion GAST,ATP1B4,MYLK4,ATP4B,GNAI3,KCNK10,KCNJ15,CALM3,EZR,SST
    Thyroid hormone signaling pathway ATP1A3,PIK3CB,PDPK1,PIK3CG,ATP1A2,ATP1B3,RXRB,PIK3R3,ITGB3,ATP2A2
    Proteoglycans in cancer PPP1R12C,ANK2,IGF2,FZD6,TFAP4,ITGB3,WNT8A,CBLC,STAT3,ITGB1

    Protein Function

    SLC9A1 has several biochemical functions, for example, calcium-dependent protein binding,calmodulin binding,phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC9A1 itself. We selected most functions SLC9A1 had, and list some proteins which have the same functions with SLC9A1. You can find most of the proteins on our site.

    Function Related Protein
    calmodulin binding MKNK1,NRGN,PHKG1A,PDE1C,PHKA1,MAPKAPK2B,PDE1B,TRPV1,NOS3,MYH7
    solute:proton antiporter activity SLC9A10,SLC9A6B,SLC9B2,SLC9A6A,NHEDC1,TMCO3,SLC9A3.1,SLC9A4,SLC9A9,SLC9A5
    protein binding, bridging BCL3,NEFH,DSP,AMFR,FKBP4,CAV1,ANXA1,STUB1,COL1A2,SH2D1B
    protein complex scaffold MAGI1,WWC3,CAV1,ISCU,MAGI1B,CNOT1,KLHL17,SEPT2,AKAP13,CAV3
    protein phosphatase 2B binding MYOZ2,PPP3CB,AKAP5,ATP2B4,BAD,SOD1,AKAP1
    sodium:proton antiporter activity SLC9A6B,SLC9A3.1,SLC9A8,SLC9A3,SLC9A5,SLC9A3.2,SLC9A6A,SLC9A4,SLC9A7,SLC9A9
    calcium-dependent protein binding NELF,S100P,CALM2,S100A1,MMP13,SYT8,A2M,NRXN1,SYN1,ANXA3
    protein binding MBNL3,OPRL1,RDBP,GRIA2,MTA1,C2orf88,GCHFR,HSFY1,ATXN7L3,TDP2
    phosphatidylinositol-4,5-bisphosphate binding SESTD1,FAM123B,FAM21C,PHLDA3,TULP3,MAPKAP1,TWF2,TULP1,TWF1,KCNQ1

    Interacting Protein

    SLC9A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC9A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC9A1.

    YWHAB;MAP3K7;CHP2;MAP4K4;UBE2I;MDFI;Rab5c;YWHAZ;Gbf1;Taf15;AP4S1;Mad2l1

    Resources

    Research Area

    Reperfusion Injury Therapeutic Targets

    References

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