SLC7A8
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Official Full Name
solute carrier family 7 (amino acid transporter light chain, L system), member 8 -
Overview
Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. -
Synonyms
SLC7A8;solute carrier family 7 (amino acid transporter light chain, L system), member 8;LAT2;LPI-PC1;large neutral amino acids transporter small subunit 2;integral membrane protein E16H;L-type amino acid transporter 2;solute carrier family 7 (amino acid transporter, L-type), member 8;solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
Recombinant Proteins
- Mouse
- Rhesus macaque
- Rat
- Human
- Mammalian Cell
- HEK293
- Mammalian cells
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC7A8-15523M | Recombinant Mouse SLC7A8 Protein | Mammalian Cell | Mouse | His |
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| SLC7A8-4314R | Recombinant Rhesus monkey SLC7A8 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SLC7A8-5579R | Recombinant Rat SLC7A8 Protein | Mammalian Cell | Rat | His |
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| SLC7A8-4130R | Recombinant Rhesus Macaque SLC7A8 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SLC7A8-4130R-B | Recombinant Rhesus Macaque SLC7A8 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| SLC7A8-4146H | Recombinant Human SLC7A8 Protein (Arg27-Ala243), C-His tagged | Mammalian cells | Human | His | Arg27-Ala243 |
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| SLC7A8-5238R | Recombinant Rat SLC7A8 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLC7A8-5238R-B | Recombinant Rat SLC7A8 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SLC7A8-8427M | Recombinant Mouse SLC7A8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC7A8-8427M-B | Recombinant Mouse SLC7A8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC7A8 involved in several pathways and played different roles in them. We selected most pathways SLC7A8 participated on our site, such as Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC7A8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein digestion and absorption | KCNK5,COL21A1,CPB2,ATP1A1,CPB1,SLC1A1,ACE2,KCNJ13,ATP1B4,CELA3A |
Protein Function
SLC7A8 has several biochemical functions, for example, L-amino acid transmembrane transporter activity,amine transmembrane transporter activity,amino acid transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC7A8 itself. We selected most functions SLC7A8 had, and list some proteins which have the same functions with SLC7A8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| amino acid transmembrane transporter activity | PEX3,SLC38A6,SLC38A11,SLC38A10,SLC38A5,SLC7A5,SLC6A17,SLC38A9,SLC38A2,SLC3A1 |
| organic cation transmembrane transporter activity | SLC22A14,SLC22A2,SLC22A1,SLC22A3 |
| amine transmembrane transporter activity | SLC22A16,AQP9 |
| L-amino acid transmembrane transporter activity | SLC7A14,SLC43A2,SLC43A2A,SLC43A1B,Nat3,SLC7A5,SLC7A13,SLC7A6,SLC7A7,SLC43A1A |
| neutral amino acid transmembrane transporter activity | SLC43A1A,SLC43A2B,SLC3A2,SLC7A10,SLC43A2,SLC15A1B,SLC6A19B,SLC6A19A,SLC43A1B,SLC1A5 |
| antiporter activity | SLC9A3.2,SLC38A3,CLCN4-2,SLC35D1A,SLC7A13,SLC26A3.1,SLC35D1B,SLC35E4,SLC4A8,CLCN5 |
| toxin transporter activity | LRP6,SLC17A3,SLC22A2,ABCG1,SLC22A3 |
Interacting Protein
SLC7A8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC7A8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC7A8.
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