SLC6A18
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Official Full Name
solute carrier family 6, member 18 -
Overview
The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, amino acids,;and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for;solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 (PubMed 16125675)). -
Synonyms
SLC6A18;solute carrier family 6, member 18;solute carrier family 6 (neurotransmitter transporter), member 18;sodium-dependent neutral amino acid transporter B(0)AT3;FLJ31236;Xtrp2;sodium channel-like protein;system B(0) neutral amino acid transport
Recombinant Proteins
- Mouse
- Rat
- Zebrafish
- Mammalian Cell
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC6A18-15498M | Recombinant Mouse SLC6A18 Protein | Mammalian Cell | Mouse | His |
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| SLC6A18-5567R | Recombinant Rat SLC6A18 Protein | Mammalian Cell | Rat | His |
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| SLC6A18-6491Z | Recombinant Zebrafish SLC6A18 | Mammalian Cell | Zebrafish | His |
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| SLC6A18-5226R | Recombinant Rat SLC6A18 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLC6A18-5226R-B | Recombinant Rat SLC6A18 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SLC6A18-8408M | Recombinant Mouse SLC6A18 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC6A18-8408M-B | Recombinant Mouse SLC6A18 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC6A18 involved in several pathways and played different roles in them. We selected most pathways SLC6A18 participated on our site, such as Amino acid transport across the plasma membrane,Na+/Cl- dependent neurotransmitter transporters,SLC-mediated transmembrane transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transmembrane transport of small molecules | SLC26A3,ATP1A1A.5,AQP8A.1,SLC13A1,NIPAL3,SLC24A6,SLC35D1A,SLC9A3.1,GABRR2A,MCOLN2 |
| Transport of inorganic cations/anions and amino acids/oligopeptides | SLC4A3,SLC12A4,SLC26A6L,SLC4A2B,SLC38A5B,SLC20A1,SLC9A3.2,SLC43A2A,SLC6A20A,SLC15A1B |
| Amino acid transport across the plasma membrane | SLC43A2B,SLC6A15,SLC38A5B,SLC7A10,SLC7A8A,SLC6A20,SLC43A2,SLC1A4,SLC6A6A,SLC7A3A |
| Na+/Cl- dependent neurotransmitter transporters | SLC6A19A,SLC6A7,SLC6A20A,SLC6A12,SLC6A11,SLC6A5,SLC6A6A,SLC6A1B,SLC6A15,SLC6A9 |
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | RHCGB,SLC6A9,SLC30A3,SLC13A5,SLC5A9,SLC6A15,SLC22A12,CP,SLC39A8,SLC2A7 |
| SLC-mediated transmembrane transport | SLC6A1A,SLCO2B1,SLC4A3,SLC6A20A,SLC9A6B,SLC8A2A,SLC22A12,SLC26A7,SLC20A1B,SLC13A4 |
Protein Function
SLC6A18 has several biochemical functions, for example, neurotransmitter:sodium symporter activity,protein binding,symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A18 itself. We selected most functions SLC6A18 had, and list some proteins which have the same functions with SLC6A18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| symporter activity | SLC16A12B,SLC5A8,SLC6A6,MFSD2A,SLC16A5,SLC16A8,SLC24A2,SLC1A7A,SLC5A4,SLC6A1A |
| transporter activity | TTPA,ABCC6,ATP5G3,SLCO1F4,RLBP1B,SYPL2B,ABCF2,SLC5A12,SYPL2A,SLC23A1 |
| neurotransmitter:sodium symporter activity | SLC6A8,SLC6A17,SLC6A20B,SLC6A1,SLC6A12,SLC6A4A,SLC6A11A,SLC6A20,SLC6A1A,SLC6A1B |
| protein binding | DCAF7,CLPX,RARRES2,MCM3,ATP7B,ALKBH8,CDC37L1,WHSC1L1,FAM81B,ATN1 |
Interacting Protein
SLC6A18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A18 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A18.
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References
- Wade, KH; Forouhi, NG; et al. Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. AMERICAN JOURNAL OF CLINICAL NUTRITION 101:202-209(2015).
- Grochans, E; Grzywacz, A; et al. The 5HTT and MAO-A polymorphisms associate with depressive mood and climacteric symptoms in postmenopausal women. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 45:125-130(2013).
